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Most countries and territories worldwide are affected by coronavirus disease 2019 (COVID-19), and some cities have become known as epicenters owing to high outbreaks. Because of the changeable and unknown nature of the virus, managers of different cities could learn from the experiences of cities that have been successful in controlling COVID-19 instead of wasting time exploring different methods. It would be even more beneficial if they analyzed the experiences of similar cities. The similarity of such cities could be examined within a geographic information system based on various criteria. This study investigated the similarities among eight cities – Wuhan, Tehran, Bergamo, Madrid, Paris, Daegu, New York, and Berlin – in terms of the COVID-19 situation (target) in these locations based on proximity factors, weather, and demographic criteria. First, the factor and target layers were prepared, and then similar cities were identified using a similarity model and different distance metrics. The results were aggregated using the Copeland method because of the different outcomes for each metric. The most similar city was identified for each selected city, and its similarity level was determined based on these criteria. The results suggested the following pairs of similar cities: Wuhan–Berlin, Tehran–Berlin, Daegu–Wuhan, Bergamo–Madrid, Paris–Madrid, and New York–Paris based on COVID-19 related data up to 15 April 2020 (target T1), and Daegu–Wuhan, Tehran–Madrid, Bergamo–Paris, Berlin–Paris, and New York–Madrid up to 8 December 2021 (target T2) with a minimum and maximum similarity rate of 82.85% and 92.36%, respectively. For similar cities, the most similar factors among the proximity criteria are the distance from bus and metro stations; among weather, the criteria are humidity and pressure; and among demographics, the criteria are male and female population ratios, literacy ratio, and death ratio from asthma and cancer, with a minimum and maximum difference of 0% and 64.94%, respectively. In addition, according to the random forests ranking results (with root mean squared error = 0.23), temperature, distance from the bank, and gender were the most important criteria for the eight studied cities. Identifying these important factors helps to determine hotspots or places of future outbreaks to choose control strategies according to the cultural and ecological conditions of each city. [ABSTRACT FROM AUTHOR]