1. Major subpopulations of Plasmodium falciparum in sub-Saharan Africa.
- Author
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Amambua-Ngwa A, Amenga-Etego L, Kamau E, Amato R, Ghansah A, Golassa L, Randrianarivelojosia M, Ishengoma D, Apinjoh T, Maïga-Ascofaré O, Andagalu B, Yavo W, Bouyou-Akotet M, Kolapo O, Mane K, Worwui A, Jeffries D, Simpson V, D'Alessandro U, Kwiatkowski D, and Djimde AA
- Subjects
- Antimalarials therapeutic use, Artemisinins therapeutic use, Ethiopia epidemiology, Genetic Loci, Ghana epidemiology, Haplotypes, Humans, Malaria, Falciparum drug therapy, Malawi epidemiology, Plasmodium falciparum isolation & purification, Polymorphism, Single Nucleotide, Selection, Genetic, Antimalarials pharmacology, Artemisinins pharmacology, Drug Resistance genetics, Malaria, Falciparum epidemiology, Malaria, Falciparum parasitology, Plasmodium falciparum drug effects, Plasmodium falciparum genetics
- Abstract
Understanding genomic variation and population structure of Plasmodium falciparum across Africa is necessary to sustain progress toward malaria elimination. Genome clustering of 2263 P. falciparum isolates from 24 malaria-endemic settings in 15 African countries identified major western, central, and eastern ancestries, plus a highly divergent Ethiopian population. Ancestry aligned to these regional blocs, overlapping with both the parasite's origin and with historical human migration. The parasite populations are interbred and shared genomic haplotypes, especially across drug resistance loci, which showed the strongest recent identity-by-descent between populations. A recent signature of selection on chromosome 12 with candidate resistance loci against artemisinin derivatives was evident in Ghana and Malawi. Such selection and the emerging substructure may affect treatment-based intervention strategies against P. falciparum malaria., (Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
- Published
- 2019
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