1. A118G mu opioid receptor polymorphism among drug addicts in Malaysia.
- Author
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Nagaya, Devaki, Ramanathan, Surash, Ravichandran, Manickam, and Navaratnam, Visweswaran
- Subjects
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OPIOID receptors , *POLYMORPHISM (Crystallography) , *PEOPLE with drug addiction , *HUMAN genetic variation , *ALLELES , *GENE frequency , *DRUG addiction - Abstract
Drug addiction is an important social problem in many countries. Genetic and environmental factors contribute to the predisposition of drug addiction. Genetic variations at the μ opioid receptor (OPRM1) gene locus have been associated with opiate addiction. The present study aims to delineate the frequency of A118G allele of OPRM1 among Malaysian subjects. The frequency of A allele and G allele were 51% and 49%, respectively for addicts and about 73% and 27% respectively for healthy volunteers. The frequency of G allele was 1.77-fold higher in addicts by odds ratio calculation at 95% Cl, which indicate the G allele to be strongly associated with addiction X2 = 15.31,P < 0.0001; odds ratio 2.51; 95% Cl (1.575-3.994), compared to healthy volunteers. A significant association was observed between A118G polymorphism in μ opioid receptor gene and drug addiction. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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