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A recent report from the University Hospital of Martinique highlights the diverse cardiac phenotypes associated with laminopathic progeroid syndromes. The study focuses on a family with a single LMNA mutation, specifically the variant c.407A>T p.Asp136Val, which has been linked to atypical progeroid syndrome and severe aortic valve stenosis. The researchers found that all family members with the syndrome exhibited heart conduction abnormalities, with degenerative cardiac diseases such as coronary artery disease and aortic stenosis occurring in some individuals. The study underscores the importance of early and thorough cardiac evaluations for patients with laminopathic progeroid syndromes. [Extracted from the article]