1. An outbreak of Salmonella serotype Typhimurium infections with an unusually long incubation period.
- Author
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Brooks JT, Matyas BT, Fontana J, DeGroot MA, Beuchat LR, Hoekstra M, and Friedman CR
- Subjects
- Adolescent, Adult, Animals, Centers for Disease Control and Prevention, U.S., Child, Child, Preschool, Cohort Studies, Dairying legislation & jurisprudence, Feces microbiology, Humans, Hydrogen-Ion Concentration, Infant, Legislation, Food, Massachusetts epidemiology, Microbial Viability, Middle Aged, Milk microbiology, Salmonella Food Poisoning blood, Salmonella Food Poisoning microbiology, Salmonella typhimurium genetics, Salmonella typhimurium growth & development, United States, Young Adult, Disease Outbreaks, Infectious Disease Incubation Period, Salmonella Food Poisoning epidemiology, Salmonella typhimurium isolation & purification, Salmonella typhimurium pathogenicity
- Abstract
A 1998 investigation of an outbreak of Salmonella serotype Typhimurium infections among children tasting unpasteurized milk during tours of a dairy farm demonstrated a distribution of unusually long incubation periods (median, 8 days; interquartile range [IQR], 6-14 days). Bacterial isolates were highly acid tolerant and contained genes associated with protection against destructive phagocytic reactive oxygen intermediates. We hypothesize that exposure to low-dose oral inoculum of a pathogen with these properties could have contributed to cases of non-typhoidal salmonellosis with the longest incubation period reported to the Centers for Disease Control and Prevention (CDC).
- Published
- 2012
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