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For a long time emotions have been kept out of the deliberate tools of science; scientists have expressed emotion, but no tools could sense and respond to their affective information. This paper highlights research at the MIT Media Laboratory aimed at giving computers the ability to comfortably sense, recognize, and respond to the human communication of emotion, especially affective states such as frustration, confusion, interest, distress, anger, and joy. Two main themes of sensing--self-report and concurrent expression--are described, together with examples of systems that give users new ways to communicate emotion to computers and, through computers, to other people. In addition to building systems that try to elicit and detect frustration, our research group has built a system that responds to user frustration in a way that appears to help alleviate it. This paper highlights applications of this research to interface design, wearable computing, entertainment, and education, and briefly presents some potential ethical concerns and how they might be addressed. [ABSTRACT FROM AUTHOR]

While reliable detection of illicit drug use is paramount to the field of addiction, current methods involving self-report and urine drug screens have substantial limitations that hinder their utility. Wearable biosensors may fill a void by providing valuable objective data regarding the timing and contexts of drug use. This is a preliminary observational study of four emergency department patients receiving parenteral opioids and one individual using cocaine in a natural environment. A portable biosensor was placed on the inner wrist of each subject, to continuously measure electrodermal activity (EDA), skin temperature, and acceleration. Data were continuously recorded for at least 5 min prior to drug administration, during administration, and for at least 30 min afterward. Overall trends in biophysiometric parameters were assessed. Injection of opioids and cocaine use were associated with rises in EDA. Cocaine injection was also associated with a decrease in skin temperature. Opioid tolerance appeared to be associated with a blunted physiologic response as measured by the biosensor. Laterality may be an important factor, as magnitude of response varied between dominant and nondominant wrists in a single patient with bilateral wrist measurements. Changes in EDA and skin temperature are temporally associated with intravenous administration of opioids and cocaine; the intensity of response, however, may vary depending on history and extent of prior use.