1. Zorrimidazolone, a bioactive alkaloid from the non-indigenous mediterranean stolidobranch Polyandrocarpa zorritensis.
- Author
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Aiello A, Fattorusso E, Imperatore C, Irace C, Luciano P, Menna M, Santamaria R, and Vitalone R
- Subjects
- Alkaloids isolation & purification, Animals, Cell Line, Tumor, Cell Survival drug effects, Drug Screening Assays, Antitumor methods, HeLa Cells, Humans, Imidazoles isolation & purification, Inhibitory Concentration 50, Mediterranean Sea, Rats, Alkaloids chemistry, Alkaloids pharmacology, Imidazoles chemistry, Imidazoles pharmacology, Urochordata chemistry
- Abstract
Chemical analysis of the Mediterranean ascidian Polyandrocarpa zorritensis (Van Name 1931) resulted in the isolation of a series of molecules including two monoindole alkaloids, 3-indolylglyoxylic acid (3) and its methyl ester (4), 4-hydroxy-3-methoxyphenylglyoxylic acid methyl ester (1) and a new alkaloid we named zorrimidazolone (2). The structure of the novel compound 2 has been elucidated by spectroscopic analysis and bioactivity of all compounds has been investigated. Zorrimidazolone (2) showed a modest cytotoxic activity against C6 rat glioma cell line.
- Published
- 2011
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