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The article titled "The New Public Art: Collectivity and Activism in Mexico Since the 1980s" analyzes the sphere of public art in Mexico from the late 20th century to the present day. The book, edited by Mara Polgovsky Ezcurra, presents ten chapters written by academics and eight dossiers written by artists and collectives. The objective of the book is to surpass the traditional notion of public art and position theory and praxis as living elements in the construction of meaning. Additionally, the book is situated between the earthquakes of 1985 and 2017, and examines how these events have affected the conception of the public in Mexico. [Extracted from the article]

Introduction: Cerebral venous thrombosis (CVT) associated with pregnancy and puerperium has long been recognized, with poor information in terms of functional outcomes. Our objective was to analyze risk factors, clinical, imaging, and laboratory variables to predict functional outcome and death in this population. Methods: CVT registries from three referral centers from Pakistan, Turkey, and Mexico, recruiting prospective cases, were combined for CVT associated with pregnancy or puerperium. Datasets and variables were standardized. Demographic characteristics, presentation, risk factors, and functional outcomes in pregnancy/puerperium-related CVT were analyzed. Binary logistic regression was used to assess predictors of outcome. The main outcome was modified Rankin score >2 at 30 days and mortality at 30 days. Results: Five hundred fifty-three cases (median age 28 years [IQR 23–34]) of CVT associated with pregnancy and puerperium were included; 439 cases (79.4%) happened in the puerperium and 20.6% during pregnancy (53.5% occurred during the first trimester). Anemia (36.7%) and dehydration (22.9%) were the commonest obstetric risk factors identified. Predictors of poor outcome (mRS >2) were encephalopathy (OR 12.8, p < 0.001), cases from Mexican origin (OR 3.1, p = 0.004), fever/puerperal infection (OR 2.7, p = 0.02), and anemia (OR 2.2, p = 0.01). Cases from Mexican origin (OR 12.0, p = 0.003) and Encephalopathy (OR 7.7, p < 0.001), presented with the highest mortality association in the final adjusted model. Discussion/Conclusion: In CVT associated with pregnancy and puerperium, encephalopathy, fever/puerperal infection, and anemia are associated with bad functional outcomes, meanwhile encephalopathy and cases from Mexican origin with higher mortality in the acute (30-days) of CVT onset. Anemia and infection are potential reversible predictors of poor outcome that clinicians should be aware of in order to prevent poor outcomes in these patients. [ABSTRACT FROM AUTHOR]

Copyright of Revista Mexicana de Neurociencia is the property of Academia Mexicana de Neurologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The COVID‐19 pandemic led to the development and emergency approval of an array of effective vaccines against SARS‐CoV‐2. Given the relatively small number of patients included in vaccine trials, postapproval epidemiological surveillance is crucial to detect infrequent vaccine‐related adverse events. We conducted a nationwide retrospective descriptive study evaluating the incidence of seizures among recipients of SARS‐CoV‐2 vaccines in Mexico from December 24, 2020 (date of administration of first doses nationwide) to October 29, 2021. Among 81 916 351 doses of any vaccine that were administered, we documented seizures in 53 patients, of which 31 (60%) were new onset seizures. The incidence rate of seizures per million doses was highest for mRNA‐1273 (Moderna) with 2.73 per million, followed by BNT162b2 (Pfizer‐BioNTech) with 1.02 per million, and Ad5‐nCoV (CanSino) with 1.01 per million. Thus, we found that seizures following SARS‐CoV‐2 vaccination are exceedingly rare events. [ABSTRACT FROM AUTHOR]

Background: Cerebral venous thrombosis (CVT) is associated with intracranial hemorrhage. Aim: To identify clinical and imaging features of CVT-associated intracranial hemorrhage. We hypothesized that higher clot burden would be associated with a higher risk of intracranial hemorrhage. Methods: We performed a retrospective analysis of an international, multicenter cohort of patients with confirmed cerebral venous thrombosis who underwent computed tomography within 2 weeks of symptom onset. Clinical and imaging features were compared between patients with and without intracranial hemorrhage. Clot burden was assessed by counting the number of thrombosed venous sinuses and veins on confirmatory imaging. Results: We enrolled 260 patients from 10 institutions in Europe and Mexico. The mean age was 42 years and 74% were female. Intracranial hemorrhage was found in 102 (39%). Among them parenchymal hemorrhage occurred in 64 (63%), in addition, small juxta-cortical hemorrhage was found in 30 (29%), subarachnoid hemorrhage in 24 (24%) and subdural hemorrhage in 11 (11%). Multiple concomitant types of hemorrhage occurred in 23 (23%). Older age and superior sagittal thrombosis involvement were associated with presence of hemorrhage. The number of thrombosed venous sinuses was not associated with intracranial hemorrhage (median number IQRInterquartile ratio] of sinuses/veins involved with hemorrhage 2 (1–3) vs. 2 (1–3) without hemorrhage, p = 0.4). Conclusion: The high rate of intracranial hemorrhage in cerebral venous thrombosis is not explained by widespread involvement of the venous sinuses. Superior sagittal sinus involvement is associated with higher bleeding risk. [ABSTRACT FROM AUTHOR]

• Equitable teacher–child interactions are comprised of generic and cultural dimensions. • Addressing cultural dimensions can amend the paradoxical development of young Latinos. • The Classroom Assessment of Sociocultural Interactions (CASI) is an observation protocol of cultural dimensions. • The CASI demonstrates good model fit and moderate reliability. • The CASI should be used with teachers for formative and research purposes. Debates continue about how to teach young Latinos and other minoritized children in the US. Latinos are a compelling case because of (1) their size and (2) their paradoxical development: strong social competencies yet relatively weak academic development. A suggestion is to provide young Latinos with classroom experiences that resonate with the ways they are socialized at home, yet cultural dimensions of teaching in early education are underspecified and reliable and valid measures do not exist. We frame equitable teacher–child interactions as the combination of generic and cultural aspects, and as a way to utilize the social assets of Latinos in classrooms to enhance their academic development. We refine an observation protocol—the Classroom Assessment of Sociocultural Interactions (CASI)—by integrating cultural concepts from the Learning by Observing and Pitching In (LOPI) paradigm with videos of K-1 classrooms in Central Mexico, and conduct a series of psychometric analyses. We find good model fit and moderate reliability for the CASI and discuss research and practice implications to foster equitable developmental opportunities for Latino children across early education settings. [ABSTRACT FROM AUTHOR]

Objetivo: Determinar el impacto del estatus de colateralidad leptomeníngea en el pronóstico funcional a 90 días de los pacientes con enfermedad carotídea sintomática (ECS) por oclusión o estenosis grave (70-99%). Antecedentes: La enfermedad de gran vaso es una de las principales causas de infarto cerebral (IC)1, aproximadamente 15% de todos los infartos cerebrales son causados por oclusión de la arteria carótida (OAC)2. La OAC está asociada a tasas de morbimortalidad elevadas3 y es un reto terapéutico debido a la poca disponibilidad de opciones terapéuticas2. La circulación colateral ha sido reconocida recientemente como un factor determinante en el riesgo de IC y en los patrones de afectación en pacientes con enfermedad carotídea4. Métodos: Estudio transversal retrospectivo; se realizó un subanálisis del protocolo aprobado por comité de ética con oficio folio 84/18 No. CEI/143/18. Se incluyeron pacientes con ECS por OAC y estenosis grave (70-99%) tratados en el Instituto Nacional de Neurología y Neurocirugía, se evaluó el grado de colateralidad en cada paciente de acuerdo a la escala Tan, se definió buen estado de colateralidad puntaje Tan 3-4, llenado >50% en el flujo distal al vaso ocluido. El objetivo primario fue la presencia de excelente pronóstico funcional a 90 días posterior al IC o ataque isquémico transitorio (AIT), escala Rankin 0-1. Los objetivos secundarios fueron la evaluación de recurrencia AIT/IC y muerte. Se realizó regresión logística multivariada con el software STATA versión 17. Resultados: Se identificó un total de 170 pacientes, con edad media de 69 años (+20), 107 (62.9%) fueron hombres. Con oclusión 91 (52.4%) pacientes y con oclusión grave 81 (47.6%). En 55 pacientes (32%; p= 0.089) se observó un excelente pronóstico funcional a 90 días, 15 presentaron recurrencia (8.7%; p=0.631) y 4 fallecieron (2.3%; p= 0.395), no se identificaron diferencias entre ambos grupos. Fue factible evaluar colateralidad en 82 pacientes, 62 (70.45%) tuvieron buen estado de colateralidad y este se asoció a un excelente pronóstico funcional a 90 días en ambos grupos, sin diferencias estadísticas después de ajustar por edad y género, con OR 4.67; (p= 0.015, CI 1.34 - 16.28). Conclusión: En pacientes con OAC, la buena colateralidad se asoció con un pronóstico funcional excelente, sin diferencias entre oclusión y estenosis grave. No se encontraron diferencias estadísticamente significativas entre la tasa de recurrencia o mortalidad entre ambos grupos. [ABSTRACT FROM AUTHOR]

Copyright of Archivos de Neurociencias is the property of Instituto Nacional de Neurologia y Neurocirugia, Departamento de Publicaciones Cientificas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archivos de Neurociencias is the property of Instituto Nacional de Neurologia y Neurocirugia, Departamento de Publicaciones Cientificas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archivos de Neurociencias is the property of Instituto Nacional de Neurologia y Neurocirugia, Departamento de Publicaciones Cientificas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background and purpose: Stroke has been scarcely studied in Latin America (LA). The Mexican Institute of Neurology Stroke Registry was established in 1990 as a prospective computer-based database to register data obtained from patients admitted with stroke. Using this data, we attempted to define the profile of risk factors and outcomes. Methods: The demographic data, stroke description, ancillary tests, vascular risk factors, and modified Rankin scale (mRs) were registered. Ischemic stroke subtyping was based on the Trial of Org 10,172 of the Acute Stroke Treatment classification. We followed-up patients using multiple overlapping methods. Primary outcomes included mRs, recurrence, and death at 30 days and at the end of follow-up. results: We included 4,481 patients with a median follow-up of 27 months, (17,281 person-years follow-up). The mean age was 52.8 ± 18 years. There were 2,229 males (50%) included in the study. CI was present in 64.9%, intracerebral hemorrhage (ICH) in 25.6%, and cerebral venous thrombosis (CVT) in 6.3%. Hypertension was the major risk factor (46.5%). The most common cause of CI was atherosclerosis (27%). ICH was mainly hypertensive (58%), and 60% of CVT were puerperal. Overall, the mortality rate was 24.5%. The recurrence rate was 16.9%. Poor outcome (mRs ≥ 3) was found in 56.2% of patients. The best outcomes were observed in CVT patients (74.5% mRs ≤ 2), whereas 72.1% ICH patients had mRs ≥3. conclusion: This is one of the largest hospital-based registries in LA and shows significant differences with other previously published registries, including a younger age, relatively less hypertension, and larger proportion of CVT. Poor functional outcome was common. This study adds to the understanding of geographic differences in stroke characteristics and outcomes. [ABSTRACT FROM AUTHOR]

The number of Mexicans leaving the U.S. is now greater than the number coming to the U.S., signaling monumental shifts in U.S.-Mexico relations. This is evoking new questions about bi-national collaboration, particularly regarding the wellbeing of transnational children and youth. Analyzing data from the Mexican Census, we identify basic demographic trends of "returnee" children and youth--those in Mexico after living in the US. Most are US-born with a Mexican-born parent, relatively young, and dispersed across the country, with concentrations in municipalities in northern and central states. We frame classroom-learning needs for these students and share descriptive findings from a recent study of equitable teaching--i.e., high quality, adequate quantity, and meaningful--through video recordings of classroom interactions in early elementary settings in the state of Aguascalientes. We conclude with a series of recommendations to enrich learning opportunities for returnee students in Mexican classrooms. [ABSTRACT FROM AUTHOR]

Copyright of Archivos de Neurociencias is the property of Instituto Nacional de Neurologia y Neurocirugia, Departamento de Publicaciones Cientificas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archivos de Neurociencias is the property of Instituto Nacional de Neurologia y Neurocirugia, Departamento de Publicaciones Cientificas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archivos de Neurociencias is the property of Instituto Nacional de Neurologia y Neurocirugia, Departamento de Publicaciones Cientificas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archivos de Neurociencias is the property of Instituto Nacional de Neurologia y Neurocirugia, Departamento de Publicaciones Cientificas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archivos de Neurociencias is the property of Instituto Nacional de Neurologia y Neurocirugia, Departamento de Publicaciones Cientificas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Children's views on their household work as mutual contribution within the family may encourage their initiative in pitching in. We asked 9- and 10-year-old children from a Mexican city how they viewed child participation in family household work. Almost all of the 16 children reported that children want to contribute to family household work, which they regarded as the shared responsibility of everyone in the family. However, the 8 children who lived in an Indigenous-heritage community were more often reported to take initiative to make broad and complex work contributions than children from a newly schooled community. The children in the Indigenous-heritage community more often emphasized their mutual coordination and collaboration with other members of the family, whereas children from the newly schooled community often focused on their personal contributions. We examine cultural values that may support children in viewing household work as part of being a responsible family member, and consider the possibility that these encourage children's development of initiative. © 2014 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

This article presents the results of research on children's collaborative participation and learning in the daily family activities of a P'urhépecha community. We believe that parents orient forms of participation according to their conceptions of pertinent activities for their children's development. The results of interviews with parents who have little educational experience and with other parents who are known for a long personal history with school, show cultural differences within the community and generational transformations among families in terms of their children's involvement in collaborative activities--which reflect on their development as individuals who contribute to their family and community. [ABSTRACT FROM AUTHOR]

This article examines the relationships among the literacy practices engaged in by first-grade children and parents at home and the ways in which these practices are communicated, shaped, and fostered by teachers and administrators in two different sociocultural environments in urban Mexico. The differences observed between the home literacy experiences of children in a working-class and a middle-class community included transgenerational communication of assumptions regarding literacy and schooling, as well as attitudes associated with the parents’ own school experiences. Class-based expectations on the part of teachers not only shaped interactions with parents, but were also reflected in the way the national curriculum was delivered, with a greater emphasis on rote skills and traditional reading instruction in the working-class community. The authors argue that the school plays a role in the co-production of cultural capital in the home through its shaping of some of the literacy practices that children and families undertake. [ABSTRACT FROM PUBLISHER]

Preeclampsia remains a major cause of worldwide pregnancy related maternal and neonatal mortality and morbidity, it accounts for more than 50,000 maternal deaths each year. The World Health Organization estimates that at least one woman dies every 7 minutes from a complication of preeclampsia. It is the main cause of maternal death in Mexico and Latin America. Standarized assessment and surveillance of women with preeclampsia is associated with reduced maternal risk. Standarized sequence was established to search for practice guidelines from the clinical questions raised on diagnosis and treatment of preeclampsia-eclampsia. The working group selected clinical practice guidelines found in the Cochrane Library, Medline y PubMed. The results were expressed as levels of evidences and grade of recommendation. Evidence suggests, that treatment of severe hypertension, seizures prophylaxis with magnesium sulfate, and management by experienced health-care professionals will improve maternal, fetal and neonatal outcomes. Treatment remains supportive with pregnancy termination being the only definitive cure. [ABSTRACT FROM AUTHOR]

Copyright of Revista Mexicana de Neurociencia is the property of Academia Mexicana de Neurologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Mexicana de Neurociencia is the property of Academia Mexicana de Neurologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archivos de Cardiología de México is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objetivo: identificar variantes genéticas relacionadas estadísticamente con el riesgo de presentar disección arterial. Antecedentes: la Disección Arterial Cérvico-Cerebral (DACC) se produce por el desgarre de la pared de la arteria carótida o vertebral, que conduce a la formación de un hematoma entre la íntima y la media ocasionando estenosis u oclusión del vaso, resultando en un infarto cerebral. Se ha formulado la hipótesis de que los pacientes con DACC, pueden tener una constitución genéticamente determinada que condiciona debilidad de la pared de los vasos, desencadenando disección arterial. Métodos: se realizó un estudio de escrutinio completo del genoma. El diseño del estudio es de casos y controles, mediante un modelo lineal mixto. Núm. de registro del protocolo: 30/15. Resultados: se incluyeron 120 casos de DACC y 132 controles. Dos SNPs presentaron un nivel sugestivo de asociación con DACC. El primero es rs12476621[C], en el intrón 7 de NCKAP5 en el cromosoma 2q21.2 (OR 2.70, IC 95% 1.68-5.25: p=6.3X10-6) y rs12950704[G], cuyo gen más cercano es el DYNLL2 en el cromosoma 17q22 (OR 0.30, IC 95% 0.20-0.76: p=6.8X10-6). Conclusiones: este es el primer escrutinio del genoma completo para Disección Arterial Cérvico Cerebral realizado en población mexicana. No encontramos asociación con el alelo rs9349379[G] (PHACTR1), que fue asociado con una disminución del riesgo de DACC en el estudio CADIPS (Debette, et al. 2015). Dos SNPs presentaron un nivel sugestivo de asociación con DACC. A ambas variantes no se les ha reportado significancia clínica ni hay reportes científicos al respecto. [ABSTRACT FROM AUTHOR]

Copyright of Archivos de Neurociencias is the property of Instituto Nacional de Neurologia y Neurocirugia, Departamento de Publicaciones Cientificas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archivos de Neurociencias is the property of Instituto Nacional de Neurologia y Neurocirugia, Departamento de Publicaciones Cientificas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background and Purpose: Elevated homocysteine (Hcy) plasma levels are associated with an increased risk of spontaneous cervical artery dissection (sCAD). We examined the potential association between Hcy, folate, vitamin B12 levels and 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms in patients with cerebral infarct caused by sCAD. Patients and Methods: 39 patients who survived a cerebral infarct caused by sCAD [20 (51%) women; 24 (61.5%) vertebral and 15 (38.5%) internal carotid arteries], and 76 healthy control subjects were included. Hcy plasma levels (fasting and after methionine load), folate and vitamin B12 levels were measured. We also performed polymorphisms of MTHFR. Hcy, vitamin B12, folates and polymorphisms of MTHFR were assessed and any associations were analyzed using multivariate statistics. Results: Mean plasma fasting Hcy level was 9.81 μmol/l for cases and 6.38 for controls (p = 0.001). The occurrence of sCAD was associated with elevated fasting Hcy levels (>95th percentile over the control group) with an adjusted odds ratio of 7.9 (95% CI 1.66–35). The association between low plasma folate values (<5th percentile) and the presence of CAD was 7.9 (95% CI 1.6–31) after adjusting for confounding variables. The distribution of the MTHFR genotype showed a higher TT mutant frequency among CAD patients (p = 0.034). Conclusions: High plasma concentrations of Hcy and low plasma levels of folate were associated with an increased risk of sCAD in the sample studied. We conclude that deficiencies in nutritional status may contribute to the relatively high incidence of CAD in Mexico. Copyright © 2007 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Background and Purpose: We describe the natural history, functional prognosis and long-term recurrences of patients with dissection of cervical arteries (DCA) in a sequential observational study. Methods: We describe 130 patients with angiographically-proven DCA admitted to the Neurology Institute in Mexico City (Mexico), and analyzed clinical and neuroimaging data, treatment and outcome. Treatment with either anticoagulation or aspirin was decided by the primary physician. Primary outcome measures were recurrence (stroke and death) and clinical outcome at 6 months. Follow-up studies were performed to determine recanalization. Results: Mean age was 35.4 years; 4 patients died (3%) and 126 were followed for 3,906 person/years; 17 patients (13%) had a heralding ischemic cerebral event (6 strokes, 11 TIAS) about 8 days before the diagnosis of DCA. After diagnosis, recurrent ischemic stroke occurred in 6 patients (4.8%) within the 2 first weeks (1.5 persons/1,000 follow-up years). No significant differences were found between aspirin and anticoagulation. Recanalization was more frequent in vertebral dissections. Complete recanalization of vertebral dissections was associated with a favorable prognosis [OR 3.2 (95% CI 1.1–8.8; p = 0.02)]. Conclusions: In Mexico, DCA affects young adults and may present with a heralding stroke or TIA. We found rare, early ischemic recurrences. Vertebral territory dissections had better prognosis than carotid ones, particularly in patients with demonstrated complete recanalization. Copyright © 2006 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Objectives: To estimate the incidence of cognitive impairment (CI) among cognitively healthy, Mexican subjects, and to evaluate the impact of demographic and vascular factors on the conversion to CI and mortality. Methods: 734 eligible subjects (aged 55 to >90 years) from a population-based sample were examined. The cognitive function of participants was assessed using the Mini-Mental State Examination (MMSE) every 2 years. The subjects were followed for an average of 3.2 years. The CI was defined using two sets of criteria: (i) moderate CI, as a drop to 25–21 on the MMSE at 2-year follow-up or a decrease of at least four points and (ii) severe CI, defined as a drop of 21 or less in MMES at follow-up. The incidence density and period prevalence were determined as epidemiological measures as well as the cumulative incidence as a risk measure. Kaplan—Meier survival curves were used to analyse the main points of interest: CI, dementia and mortality. Results: The period prevalence of moderate CI was 20%, and 10% for severe CI. During 1959 person-years of follow-up, severe CI developed in 33 of the 361 participants. While during 2096 person-years of follow-up; 80 of 361 participants developed moderate CI. The rate of progression to severe CI in moderate CI subjects gradually increases with follow-up. Both, moderate and severe CI were associated with low educational level, higher age and higher mortality. Conclusions: Elderly people with moderate CI have an increased risk of severe CI. Moderate and severe CI are both predictive of higher mortality in Mexican subjects. [ABSTRACT FROM AUTHOR]

AbstractBackground and Purpose: Phenylpropanolamine (PPA) has been associated with an increased risk of intracranial hemorrhage (ICH). The aim of this study was to assess the association between PPA intake and ICH in a Mexican population. Methods: We included all patients with ICH aged 18 to 51 years, with no known structural etiology, diagnosed from January 1991 to December 2000. Three to 4 controls per patient matched by sex, age (within 5 years) and place of residence were included. Patients and controls were asked about use of cold medication or appetite suppressant medications within the previous year before the interview. We considered a PPA related hemorrhage when there was a temporal relationship between the use of medication and the development of the hemorrhage, and when other causes could be ruled out. Associated risks for PPA use and other possibly related variables were estimated. Results: 177 patients (mean age 39 ± 12 years) were included; 58 (33%) were diagnosed with subarachnoid hemorrhage (SAH) and 119 (67%) with ICH. 41.2% (73 of 177) of patients had documented use of PPA within the past year and 10 (5.7%) of them had a temporal relationship between ingestion of PPA and ICH. In control subjects 42.4% (422 of 996) had been exposed to PPA and none of them developed hemorrhage. The time from PPA exposure to the onset of ICH varied from 30 minutes to 24 hours. The risk of PPA exposure for hemorrhage was not significant in cases or controls, OR 0.95 (95% CI, 0.68 to 1.34; p = 0.77). No subjects (cases or controls) reported use of PPA as an appetite suppressant. Conclusions: We found no association between ingestion of PPA and cerebral hemorrhage with respect to ingestion of PPA in the previous year. When recent use was looked at an apparent risk was evident.Copyright © 2003 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Regrettably, stroke has been scarcely studied in México, and the available data suffer from great variability in diagnostic testing, risk factor definitions, and poor generalizability. The current cumulative incidence of stroke in Mexico is 232·2 per 100 000, whereas prevalence among people aged 60 years or older is 18·2 per 1000. Hypertension and diabetes are the main risk factors. Ischemic stroke is the most frequent sub-type. Stroke mortality has been increasing during last years, and 30-day case fatality rate doubles at one-year follow-up. A remarkable finding of a hospital-based registry was that most of ischemic stroke cases are of undetermined etiology and even when a quarter of patients arrive on time for thrombolysis, less than 1% received this management. [ABSTRACT FROM AUTHOR]

Background: Spontaneous, nontraumatic intracerebral hemorrhage (ICH) is a subtype of stroke that causes a great amount of disability and economic and social burden. This is particularly true in developing countries where it accounts for between 20% and 50% of all strokes. Pharmacological and surgical interventions have been attempted to reduce the mortality and disability caused by ICH, with unsuccessful results. Recently, the use of fluoxetine in addition to physical rehabilitation has been proven useful to improve motor recovery following cerebral infarct. The purpose of this study is to test whether a 3-month treatment with fluoxetine enhances motor recovery in nondepressed patients with acute intracerebral hemorrhage.Methods/design: Our study is a randomized, double-blind, placebo-controlled, multicenter clinical trial. We will recruit 86 patients with intracerebral hemorrhage of both sexes, aged >18 years, from four Mexican hospitals. The patients will receive either 20 mg of fluoxetine or a placebo once daily for 90 days. The primary outcome is the mean change in the Fugl-Meyer Motor Scale score between inclusion (day 0) and day 90. The secondary outcomes will be changes in the Barthel Index, the Modified Rankin scale and the National Institutes of Health stroke scale. The outcomes will be measured at day 42 ± 7 days and at day 90, for a total of four visits with each subject (at screening and at 0, 42 and 90 days).Discussion: Current guidelines recommend early supported hospital discharge and home-based rehabilitation programs as the only cost-effective intervention to aid the recovery of patients with intracerebral hemorrhage. Nevertheless, such interventions are dependent on available resources and funding, which make them very difficult to implement in developing countries. We believe that the identification of a helpful pharmacological intervention to aid the motor recovery of these patients will constitute a breakthrough that will have a major impact in reducing the burden of disease caused by this subtype of stroke worldwide, especially in the developing world.Trial Registration: Current Controlled Trials NCT01737541. [ABSTRACT FROM AUTHOR]