Objective: To review the incidence of cases of gastroschisis in the Hospital Universitario Dr. José E. González (HU) and to analyze possible genetic and environmental causes. Methods: Data obtain from hospital registries from 1998-2008 were used to obtain the frequency of cases. Maternal and paternal age, associated anomalies, clinical outcomes, prenatal exposure to teratogens and other parameters were obtained from medial registries. Results: There were around 4500 births per year from 1998 with a significant increase of adolescent mothers in the last five years. A total of 46 neonates with gastroschisis were admitted from 1/ 1998 to 12/2008, the incidence rate was 11.1 /10,000 in 2004 and 23/10,000 in 2008. The mortality was of 35%. We only had access to 26 medical records. The mean paternal age was 27.65 (17-49) and maternal age was 21.2 years (15-40 years), 61.5% were teenagers. From these, 65% were primiparous, five had a history of alcohol use and of tobacco in four of them and 77% had a history of taking prenatal folic acid. Nineteen percent of the newborns were preterm with a mean gestational age of 37 wks (32-40 wks). Major and minor malformations were associated in 30% of cases. Karyotype performed in two cases showed chromosome abnormalities: 46, XY, ins (10q11.2) and 46, XX, dup (Xp22.1) the last one associated to atrial septum defect. Conclusion: Incidence of gastroschisis has been rising at the University Hospital in Monterrey, Mexico associated with an increase in pregnancies in teenagers. Chromosomal aberrations found have not been reported previously. [ABSTRACT FROM AUTHOR]