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The effluents deriving from agricultural industries are sources of wastewater sensibly different from common civil wastewater treatment plants effluents, because they are characterized by significant amounts of nutrients and organic load. Agricultural industries require considerable water volumes for processing the farm products, in doing so generating huge volumes of wastewater, with high concentration of chemical oxygen demand (COD), nitrogen (N) and phosphorus (P). Advanced and low cost techniques for water depuration are required in such circumstances, as the use of Integrated System of Phytodepuration (ISP). In the present work, three different case studies (a dairy, a pig feedlot and a vinegar industry) are investigated: the performances of the ISPs were evaluated analyzing raw wastewaters and final effluents over a period ranging from 2 to 4 years. The results obtained show that the designed ISPs are characterized by a mean efficiency value higher than 85% for COD removal, 73% for N and 85% for P. Moreover, for the pig feedlot the ISP final effluent is characterized by a quality level not only suited for the release into surface waters but also for irrigation, while for the other two case studies is possible to release the final effluent in surface water.