1. A new quassinoid from Castela texana.
- Author
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Dou J, McChesney JD, Sindelar RD, Goins DK, and Walker LA
- Subjects
- Animals, Antimalarials pharmacology, Antineoplastic Agents, Phytogenic pharmacology, Antiprotozoal Agents pharmacology, Giardia drug effects, Mexico, Plasmodium falciparum drug effects, Texas, Triterpenes pharmacology, Trypanocidal Agents pharmacology, Tumor Cells, Cultured, Antineoplastic Agents, Phytogenic isolation & purification, Antiprotozoal Agents isolation & purification, Plants, Medicinal chemistry, Triterpenes isolation & purification
- Abstract
A new quassinoid, 11-O-trans-p-coumaroyl amarolide (1) was isolated from Castela texana, and the structure was elucidated by spectroscopic analysis. Compound 1 is the first coumaroyl quassinoid derivative to have been isolated from nature. The known compounds amarolide (2), chaparrinone, chaparrin, glaucarubolone, holacanthone, and 15-O-beta-D-glucopyranosyl glaucarubol were also isolated. All isolated compounds were tested for their cytotoxicity and antiprotozoal activities.
- Published
- 1996
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