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1. A multi-trial diagnostic tool in fin whale (Balaenoptera physalus) skin biopsies of the Pelagos Sanctuary (Mediterranean Sea) and the Gulf of California (Mexico).

Author

Fossi MC, Urban J, Casini S, Maltese S, Spinsanti G, Panti C, Porcelloni S, Panigada S, Lauriano G, Niño-Torres C, Rojas-Bracho L, Jimenez B, Muñoz-Arnanz J, and Marsili L

Subjects
Animals, Biopsy methods, Biopsy veterinary, Blotting, Western, Female, Gene Expression Profiling, Male, Mediterranean Sea, Mexico, Skin, Biomarkers analysis, Environmental Monitoring, Fin Whale, Water Pollutants, Chemical analysis
Abstract

The main objective of this study was to apply a set of sensitive non-lethal biomarkers in skin biopsies of fin whales (Balaenoptera physalus) to evaluate the toxicological status of this mysticete in the Pelagos Sanctuary (Mediterranean Sea) and in the Gulf of California (Sea of Cortez-Mexico). We developed a "multi-trial diagnostic tool" (based on field and in vitro studies), combining molecular biomarkers (western blot of CYP1A1, CYP2B) and gene expression (qRT-PCR of HSP70, ERα, AHR, E2F-1) with the analysis of OCs, PAHs and PBDEs. The study revealed a higher level of toxicological stress in the Mediterranean fin whales., (Copyright © 2009 Elsevier Ltd. All rights reserved.)

Published
2010
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