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1. Biological study of alcohol dependence syndrome with reference to ethnic difference: report of a WHO Collaborative Study.

Author

Yamashita I, Ohmori T, Koyama T, Mori H, Boyadjive S, Kielholz P, Gastpar M, Moussaoui D, Bouzekraoui M, and Sethi BB

Subjects
Alcoholism enzymology, Ethanol metabolism, Europe ethnology, Female, Humans, Japan, Male, Mexico ethnology, Philippines ethnology, Schizophrenia enzymology, Schizophrenia ethnology, World Health Organization, Alcoholism ethnology, Aldehyde Oxidoreductases deficiency
Abstract

Inherited deficiency of acetaldehyde dehydrogenase type I (ALDH-I) was found in 43% (50/117) of normals, 33% (27/82) of schizophrenics, but only 4% (5/113) of alcoholics among Japanese. The ALDH-I deficiency was never found, however, in 146 mostly schizophrenic subjects from Europe (Basel, Moscow, Zagreb), Australia (Nedlands), India (Lucknow), Morocco (Casablanca) and Mexico (Mexico City). It was demonstrated that ALDH-I deficiency produces the flushing syndrome which inhibits the development of drinking habit and alcohol dependence syndrome.

Published
1990
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