1. New sesquiterpene quinols from a Micronesian sponge, Aka sp.
- Author
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Mukku VJ, Edrada RA, Schmitz FJ, Shanks MK, Chaudhuri B, and Fabbro D
- Subjects
- Animals, Chromatography, High Pressure Liquid, Cyclin D1 drug effects, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinases drug effects, Inhibitory Concentration 50, Micronesia, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Sesquiterpenes chemistry, Sesquiterpenes pharmacology, Porifera chemistry, Proto-Oncogene Proteins, Sesquiterpenes isolation & purification
- Abstract
Three new sesquiterpene quinols (1, 2, and 5) and two known ones (3 and 4) were isolated along with halistanol sulfate (6) from a marine sponge of the genus Aka collected from Yap Island, Federated States of Micronesia. Their structures were determined from spectral data, and the structure of siphonodictyal C (3) was revised. Sulfates 3 and 6 inhibit CDK4/cyclin D1 complexation, whereas 1 and 4 do not.
- Published
- 2003
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