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To investigate the effects of diabetes (DM) on blood biochemical indexes, cardiac indexes and quality of life in patients with heart failure (HFpEF) with ejection fraction retention. The 246 patients with HFpEF from January 2017 to May 2019 were selected as the research objects. They were divided into DM-HFPEF group (n=98) and NDM-HFPEF group (n=148) according to whether DM was concurrent or not. The baseline data and blood biochemical indexes of the two groups were compared. The heart function parameters were detected by echocardiography. The quality of life of the patients was evaluated by Minnesota Heart Failure Quality of Life Questionnaire (MLHFQ). There were statistically significant differences in body weight, systolic blood pressure, proportion of patients with coronary heart disease and proportion of patients with hypertension between the two groups (P<0.05). Compared with NDM-HFpEF group of patients, the white blood cell count (WBC), neutrophil counts (N), serum creatinine (Scr), triglyceride (TG), fasting blood glucose (FBG), postprandial 2 hours blood glucose (2 HPBG), K+ levels of patients with DM-HFpEF group were increased. Hemoglobin (Hb), high-density lipoprotein cholesterol (HDL-C) level decreased (P<0.05). The end-diastolic left ventricular volume index (LVEDVI) of the DM-HFpEF group was lower than that of the NDM-HFpEF group, and the interventricular septal thickness (IVS), left ventricular posterior wall thickness (PWTD), E peak, E/e' were higher than those of the NDM-HFpEF group, the differences were statistically significant (P<0.05). The scores of physical limitation, social limitation, emotion, and economy and total scores in MLHFQ in patients with DM-HFpEF group were higher than those in patients with NDM-HFpEF group, the differences were statistically significant (P<0.05). DM promotes the thickening of IVS and PWTD in patients with HFPEF, it can reduce diastolic function and quality of life. It also aggravates the metabolism disorder of blood glucose and blood lipid in patients with HFPEF. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of diabetes (DM) on blood biochemical indexes, cardiac indexes and quality of life in patients with heart failure (HFpEF) with ejection fraction retention. The 246 patients with HFpEF from January 2017 to May 2019 were selected as the research objects. They were divided into DM-HFPEF group (n=98) and NDM-HFPEF group (n=148) according to whether DM was concurrent or not. The baseline data and blood biochemical indexes of the two groups were compared. The heart function parameters were detected by echocardiography. The quality of life of the patients was evaluated by Minnesota Heart Failure Quality of Life Questionnaire (MLHFQ). There were statistically significant differences in body weight, systolic blood pressure proportion of patients with coronary heart disease and proportion of patients with hypertension between the two groups (P<0.05). Compared with NDM-HFpEF group of patients, the white blood cell count (WBC), neutrophil counts (N), serum creatinine (Scr), triglyceride (TG) fasting blood glucose (FBG), postprandial 2 hours blood glucose (2 HPBG), K+ levels of patients with DM-HFpEF group were increased. Hemoglobin (Hb), high-density lipoprotein cholesterol (HDL-C) level decreased (P<0.05). The end-diastolic left ventricular volume index (LVEDVI) of the DM-HFpEF group was lower than that of the NDM-HFpEF group, and the interventricular septal thickness (IVS) left ventricular posterior wall thickness (PWTD), E peak, E/e' were higher than those of the NDM-HFpEF group, the differences were statistically significant (P<0.05). The scores of physical limitation, social limitation, emotion, and economy and total scores in MLHFQ in patients with DM-HFpEF group were higher than those in patients with NDM-HFpEF group, the differences were statistically significant (P<0.05). DM promotes the thickening of IVS and PWTD in patients with HFPEF, it can reduce diastolic function and quality of life. It also aggravates the metabolism disorder of blood glucose and blood lipid in patients with HFPEF. [ABSTRACT FROM AUTHOR]