1. Effective compounds group of Mongolian prescriptions BAIMAI-SAN protect against peripheral neuropathy in lower limbs of rats through neuro protective effect.
- Author
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Liu QS, Pang ZR, Liu R, He GR, Cui J, and Yin XY
- Subjects
- Animals, Brain cytology, Brain drug effects, Cell Culture Techniques, Cell Survival drug effects, Cells, Cultured, Diabetes Complications physiopathology, Diabetes Mellitus, Experimental drug therapy, Drugs, Chinese Herbal chemistry, Drugs, Chinese Herbal pharmacology, Female, Hindlimb, L-Lactate Dehydrogenase metabolism, Male, Medicine, Traditional, Mongolia, Neural Conduction physiology, Neurites drug effects, Neurons metabolism, Neurons pathology, Neurons physiology, Neuroprotective Agents analysis, Neuroprotective Agents pharmacology, Pain etiology, Pain physiopathology, Peripheral Nervous System Diseases etiology, Peripheral Nervous System Diseases physiopathology, Plants, Medicinal, Rats, Rats, Sprague-Dawley, Rats, Wistar, Sciatic Nerve drug effects, Sciatic Nerve physiopathology, Sensory Receptor Cells drug effects, Sensory Receptor Cells physiology, Sorbitol, Diabetes Complications drug therapy, Drugs, Chinese Herbal therapeutic use, Neural Conduction drug effects, Neurons drug effects, Neuroprotective Agents therapeutic use, Peripheral Nervous System Diseases drug therapy, Phytotherapy
- Abstract
Ethnopharmacological Relevance: BAIMAI-SAN prescription is a famous Chinese minority complex prescription used for curing neuropathy., Materials and Methods: The Effective Compounds Groups of BAIMAI-SAN (ECGBM) is determined by high through-put screening, and it includes picroside II, verbascose, taurine and ellagic acid and borneol. To research the potential protective effect of ECGBM on the function of peripheral neuropathy, diabetic rats with peripheral neuropathy were induced by streptozotocin and treated with ECGBM (0.1, 0.3, 0.9 mg/kg/day i.g.) for 75 days. Primary cortical neuronal cultures were subjected to high d-glucitol, and treated with ECGBM prophylactically., Results: The administration resulted in reductions in speed of sciatic motor nerve conduction velocity (MNCV), sensory nerve conduction velocity (SNCV) and response speed to pain in the sciatic nerve fiber. Data from primary cortical neuronal cultures experiments indicated that neuronal survival rates were increased, and LDH release was decreased and the loss of neurite length was alleviated in ECGBM group., Conclusions: It is first report that ECGBM could protect the peripheral neuron in diabetic rat in vivo and in vitro. This activity may be associated with the neuron protective effect., (Crown Copyright © 2011. Published by Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2011
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