Matsuoka, Hiroyuki, Wang, Jichun, Hirai, Makoto, Arai, Meiji, Yoshida, Shigeto, Kobayashi, Tamaki, Jalloh, Amadu, Lin, Khin, and Kawamoto, Fumihiko
We conducted a survey of malaria diagnoses and treatments in remote areas of Myanmar. Blood specimens from more than 1,000 people were collected by the finger-prick method, and 121 (11%) of these people were found to be glucose-6-phosphate dehydrogenase (G6PD) deficient. Of these 121, 50 consented to analysis of theG6PDgenome. We read theG6PDsequences of these subjects and found 45 cases of G6PD Mahidol (487G>A), two of G6PD Coimbra (592C>T), two of G6PD Union (1360C>T), and one of G6PD Canton (1376G>T). Taken together with data from our previous report, 91.3% (73/80) of G6PD variants were G6PD Mahidol. This finding suggests that the Myanmar population is derived from homogeneous ancestries and are different from Thai, Malaysian, and Indonesian populations. [ABSTRACT FROM AUTHOR]