1. Evaluation of some immunological parameters in persistent allergic patients suffer nasal Staphylococcus aureus.
- Author
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Al-Sadawi, Aqeel A., Alquraishi, Zahraa Hameed Oda, and Eidan, Ali J.
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BACTERIAL colonies ,STAPHYLOCOCCAL diseases ,ALLERGIC rhinitis ,SURGICAL swabs ,ALLERGIES - Abstract
Staphylococcus aureus is a typical bacterium associated with the most common community- and hospital-acquired illnesses and has long been recognized as a significant issue in public health. S.aureus nasal carriage has immune-modulating effects in atopic dermatitis patients and may be a factor in allergic rhinitis patients' inflammatory airways and allergic reactions. The purpose of this study is to look at the prevalence of nasal S. aureus infection in individuals with chronic allergic rhinitis and its potential impact on immunological markers. Between March 2022 and November 2022, 100 patients with allergic rhinitis who visited Al-Sadder Medical City, an ENT outpatient clinic in the Najaf governorate, were included in the first group (patient groups). There were 100 healthy volunteers in the control group who weren't allergic and didn't have any respiratory issues. To isolate S. aureus from each group's nasal swab, sterile cotton swabs were used. Serum concentrations of IL-4, IFN- γ, and total IgE were then determined ELISA technique. In contrast to 24/100 controls, S. aureus was discovered in 52/100 allergic patients (P.001). The total IgE-levels of allergic S. aureus carriers were considerably greater as compared to patients non-suffered from allergic. Nasal S. aureus carriers showed greater levels of IL-4 than non-carrier individuals (p=0.037). IFN- γ was elevated in individuals who were not S. aureus carriers compared to those who were (P=0.05), and this was associated with elevated total IgE in allergic patients. Without a doubt, allergic rhinitis increases S. aureus colonization, and this might place these individuals at higher risk for more serious staphylococcal infections and found the immunological parameters(IL-4, IFN- γ, and total IgE) were significant differences between allergic S. aureus carriers compared to allergic non-carriers. More research is needed, such as attempts to eradicate staphylococcal infection and reassessment of illness and serological biomarkers. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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