Search

Background: A case-control study examined the relationship between bacterial prostatitis and IL-35 blood levels in the emergence of male infertility. Objective: This study aimed to assess the role that bacterial prostatitis and IL-35 play in the progression of male infertility in patients from Najaf province. Patients and Procedures: 120 patients were seen at AL-Sadder Medical City, Al-Najaf province through the period from January to June, 2021. This number included sixty prostatitis-related infertile patients, 30 prostatitis-related fertile patients, and 30 infertile patients. 30 healthy fertile male subjects served as control group. All subjects provided blood and semen samples and three ml of the blood were placed in a gel tube to separate the serum used to calculate IL-35 level by ELISA. A loop of semen was collected to identify the bacterial culprits as well as semen liquefaction, volume, appearance, and fundamental sperm characteristics in the residual semen (density, motility, viability, and morphology). Results: Prostatitis patients had considerably lower serum concentrations of IL-35 than infertile patients did, according to the findings (P< 0.05). The concentration of IL-35, which is thought of as a biomarker for a progressive state, decreased with the severity of the disease. The findings showed that S. aureus and E. coli were the most frequent bacterial causes of prostatitis. Conclusion: The current study found a correlation between infertility and the infection with prostatitis condition, which is reflected in the body's immune response as a lower level of IL-35. [ABSTRACT FROM AUTHOR]