1. Long-term Consequences of the Early Treatment of Children with Congenital Hypothyroidism Detected by Neonatal Screening in Nanjing, China: a 12-year Follow-up Study.
- Author
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Sun, Qing, Chen, Yu-Lin, Yu, Zhang-Bin, Han, Shu-Ping, Dong, Xiao-Yue, Qiu, Yu-Fang, Sha, Li, and Guo, Xi-Rong
- Subjects
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CONGENITAL hypothyroidism , *PEDIATRIC therapy , *DISEASE prevalence , *BODY mass index , *DEVELOPMENTAL delay , *FOLLOW-up studies (Medicine) , *THERAPEUTICS - Abstract
This study was performed to investigate the prevalence of congenital hypothyroidism (CH) in neonates in Nanjing, China and the long-term consequences of early treatment. A total of 442 454 neonates were screened for CH and 183 neonates were confirmed, with a prevalence of 1 in 2418. Of these, 163 neonates completed the follow-up process and 163 healthy children were recruited as the control group. The height, weight and body mass index (BMI) of the children with CH from 0.5 to 6 years were not significantly different from the control group (p > 0.05). The children with CH had a significantly increased risk for being overweight or obese between 0.5 and 6 years (p < 0.05). The children with CH showed a significantly lower developmental quotient (DQ) than the control group in all four areas of the Gesell test (p < 0.05). The results suggest that children with CH that has been identified by newborn screening and early treatment have normal growth and neuromotor development. [ABSTRACT FROM PUBLISHER]
- Published
- 2012
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