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A stress path with continuous rotation of the principal stress direction and continuous alteration of amplitude of deviatoric stress difference under the interaction of wave and earthquake loading was proposed based on the characteristics of the stress path under wave and earthquake loading, respectively. Using a GDS dynamic hollow cylinder apparatus, a series of cyclic triaxial-torsional coupling shear tests were performed on Nanjing saturated fine sand via the stress path mentioned previously under different relative densities, effective initial confining pressures, plastic fines contents, and loading frequencies to study the development of excess pore water pressure (EPWP) of saturated sand under the interaction of wave and earthquake loading. It was found that the development of EPWP follows the trend of fast-steady-mutative-drastic, which is different from that under the cyclic triaxial test or wave loading. The number of cycles causing initial liquefaction (NL) of saturated sand increases remarkably with relative densities. However, the relationships between NL and effective initial confining pressures, plastic fines content, or loading frequencies are more complex. [ABSTRACT FROM PUBLISHER]