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Promoting the coordinated development of regional population, economy and environment is beneficial to the realization of sustainable development. Based on the construction of evaluation index system of coordinated development of systems, the entropy weight-TOPSIS method and coupling coordination model, the coordinated development degree of population, economy and environment system in Nanjing was measured, and the temporal variation characteristics of each subsystem and their coordinated development degree form 1997 to 2016 were analyzed. The results showed that the development of population, economy system and environment system in Nanjing was generally in a continuous upward trend. Among them, the economy system developed fastest. The coordinated development degree of population, economy system and environment system in Nanjing was constantly increasing but still at a low level; the degree was only in the primary coordination phase, and its type was environment lagging. The economy subsystem and environment subsystem were important factors restricting the development of population, economy and environment in Nanjing, and the main obstacle factor was the production of industrial solid waste. The results above can provide a scientific basis for promoting the coordinated development of population, economy and environment system in Nanjing and achieving regional sustainable development. [ABSTRACT FROM AUTHOR]