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A study conducted at the University of Nebraska in Lincoln has investigated the role of a gene called hsaf-orf1 in the biosynthesis of an antifungal compound called HSAF in the bacterium Lysobacter enzymogenes. The researchers found that hsaf-orf1 is involved in the import of small sugars, which are important for the regulation and production of HSAF and its analogs. The study provides new insights into the biosynthesis and regulation of HSAF, which could have implications for the development of antifungal drugs. The research has been peer-reviewed and published in the journal Tetrahedron. [Extracted from the article]