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INTRODUCTION Nepal due to its geographical condition, inadequate resuscitation on time, and lack of full-time intensivist in a trauma team is a cause of trauma-related morbidity and mortality. MATERIAL AND METHODS It was a prospective, descriptive observational cross-sectional study in a level three intensive care unit of National Medical College for six months. All patients >18 years with a history of road traffic accidents, falls, drowning, physical assaults, and self-inflicted violence admitted to the mixed intensive care unit of a tertiary care hospital were included in this study. RESULTS One hundred and ninety-one patients were included in this study. 152 (79.5%) were males and 39 (20.4%) were females. Road traffic accident was the most common mode of injury in 166 (86.9%) patients. 178 (93.1%) patients survived and went home, 10 (5.3%) expired, 2 (1%) left the hospital against medical advice (LAMA) and 1 (0.5%) gave do not resuscitate orders (DNR). The mean days on the mechanical ventilator was 3.39 ±2.57 days. Mortality in an intubated patient was 8.6%. Mean length of stay (LOS) in the intensive care unit (ICU) was 4.28 ±4.12 days. Sequential organ failure assessment (SOFA) and acute physiology and chronic health evaluation (APACHE) II scores were a good predictor of outcome, with the SOFA score being the most effective injury severity score predicted mortality with a sensitivity of 88.9%, a specificity of 22%, with an area under receiver operating characteristic (AUROC) curve of 0.543 ±0.092 with cut off score of 5.5. CONCLUSION There should be public awareness, and political commitment to reduce the incidence of road traffic accidents and a trauma team consisting of full-time intensivist should be established to decrease the mortality in the intensive care unit. [ABSTRACT FROM AUTHOR]