1. Performance of prostate cancer antigen 3 (PCA3) and prostate-specific antigen in Prescreened men: reproducibility and detection characteristics for prostate cancer patients with high PCA3 scores (≥ 100).
- Author
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Roobol MJ, Schröder FH, van Leenders GL, Hessels D, van den Bergh RC, Wolters T, and van Leeuwen PJ
- Subjects
- Aged, Biopsy, Freezing, Humans, Male, Middle Aged, Netherlands, Predictive Value of Tests, Prognosis, Prostatic Neoplasms immunology, Prostatic Neoplasms pathology, Reproducibility of Results, Sensitivity and Specificity, Specimen Handling, Antigens, Neoplasm urine, Mass Screening methods, Prostate-Specific Antigen blood, Prostatic Neoplasms diagnosis
- Abstract
Background: Prostate cancer antigen 3 (PCA3) is considered to be prostate cancer (PCa) specific and highly overexpressed in cancer. Therefore a high PCA3 score should result in a high positive predictive value (PPV) and specificity for a positive biopsy., Objective: Our aim was to reevaluate, retest PCA3, and rebiopsy men with an initial PCA3 ≥ 100 and no PCa detected and compare the results with a random cohort of men with an initial PCA3<100., Design, Setting, and Participants: We invited men 63-75 yr of age with a PCA3 ≥100 for retesting and a control group with an initial PCA3 < 100 to participate in the European Randomized Study of Screening for Prostate Cancer, section Rotterdam., Interventions: Blood and urine sampling were used to determine prostate-specific antigen (PSA) and PCA3. Prostate biopsies were performed if the PSA was ≥2.5 ng/ml and/or the PCA3 score was ≥ 35., Measurements: We correlated the initial and reevaluated PCA3 scores. Our assessment of the PPV after rebiopsy was based on the newly determined PCA3 score., Results and Limitations: After a mean study period of 19 mo, more cases of PCa were detected in rebiopsied men with initial PCA3 scores ≥ 100 than in the controls with PCA3 scores < 100 (30.0% vs 18.8%). Combining initial and rebiopsy data resulted in a PPV of 52.2% in men with PCA3 ≥ 100. Over time, changes in PSA and PCA3 levels were quite different., Conclusions: In spite of our rescreened population, PPV and specificity were comparable with all reported studies of men with PCA3 scores ≥ 100. These findings do not explain why these PCA3 scores were excessively high in spite of the absence of biopsy-detectable PCa., (Copyright © 2010 European Association of Urology. Published by Elsevier B.V. All rights reserved.)
- Published
- 2010
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