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Background Assessing the duration of immunity following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a first priority to gauge the degree of protection following infection. Such knowledge is lacking, especially in the general population. Here, we studied changes in immunoglobulin isotype seropositivity and immunoglobulin G (IgG) binding strength of SARS-CoV-2–specific serum antibodies up to 7 months following onset of symptoms in a nationwide sample. Methods Participants from a prospective representative serological study in the Netherlands were included based on IgG seroconversion to the spike S1 protein of SARS-CoV-2 (N = 353), with up to 3 consecutive serum samples per seroconverted participant (N = 738). Immunoglobulin M (IgM), immunoglobulin A (IgA), and IgG antibody concentrations to S1, and increase in IgG avidity in relation to time since onset of disease symptoms, were determined. Results While SARS-CoV-2–specific IgM and IgA antibodies declined rapidly after the first month after disease onset, specific IgG was still present in 92% (95% confidence interval [CI], 89%–95%) of the participants after 7 months. The estimated 2-fold decrease of IgG antibodies was 158 days (95% CI, 136–189 days). Concentrations were sustained better in persons reporting significant symptoms compared to asymptomatic persons or those with mild upper respiratory complaints only. Similarly, avidity of IgG antibodies for symptomatic persons showed a steeper increase over time compared with persons with mild or no symptoms (P  = .022). Conclusions SARS-CoV-2–specific IgG antibodies persist and show increasing avidity over time, indicative of underlying immune maturation. These data support development of immune memory against SARS-CoV-2, providing insight into protection of the general unvaccinated part of the population. Clinical Trials Registration NL8473 (the Dutch trial registry). [ABSTRACT FROM AUTHOR]

A description of the course "Water Education: Curriculum Framework" that has been designed for students of the Netherlands by using social sciences standards of the curriculum "National Curriculum Standards for Social Studies: A Framework for Teaching, Learning and Assessment."

The authors discuss and analyse the complex interplay between rail transport and urban development around railway stations in the Netherlands. Although this interrelationship, known as transit-oriented development (TOD), has been theorised and studied in the academic literature, the complex and dynamic underlying mechanisms and the appropriate planning and management responses have yet to be understood sufficiently. This is particularly relevant for local, regional, and national policy makers in the various planning subsystems. In order to improve the understanding and management of the dynamic relationship between rail transport and urban development, a conceptual model of TOD was developed. Actors validate and learn from this model in the serious game SPRINTCITY, in which a rail corridor is developed over a period of twenty years. It is hypothesised that playing SPRINTCITY helps actors to understand factors, other actors, and potential barriers related to TOD. Research data were collected through debriefings, questionnaires, and model output from more than thirty sessions conducted between 2010 and 2012. The authors conclude that the combined and iterative use of modelling and gaming was effective from the perspectives of design (development of the TOD model), research (insight acquired on TOD), and policy (policy-oriented learning and analysis). [ABSTRACT FROM AUTHOR]