1. The Mini-Addenbrooke's Cognitive Examination: A New Assessment Tool for Dementia.
- Author
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Hsieh, Sharpley, McGrory, Sarah, Leslie, Felicity, Dawson, Kate, Ahmed, Samrah, Butler, Chris R., Rowe, James B., Mioshi, Eneida, and Hodges, John R.
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SCALING (Social sciences) , *DIAGNOSIS of dementia , *MEDICAL screening , *COGNITIVE testing , *COMPARATIVE studies , *DEMENTIA , *DIFFERENTIAL diagnosis , *DISCRIMINANT analysis , *EXPERIMENTAL design , *NEUROPSYCHOLOGICAL tests , *RESEARCH methodology , *NATIONAL health services , *NEURORADIOLOGY , *RESEARCH funding , *PREDICTIVE validity , *CONTROL groups , *SEVERITY of illness index , *RESEARCH methodology evaluation , *DESCRIPTIVE statistics , *TERTIARY care - Abstract
Background/Aims: We developed and validated the Mini-Addenbrooke's Cognitive Examination (M-ACE) in dementia patients. Comparisons were also made with the Mini Mental State Examination (MMSE). Method: The M-ACE was developed using Mokken scaling analysis in 117 dementia patients [behavioural variant frontotemporal dementia (bvFTD), n = 25; primary progressive aphasia (PPA), n = 49; Alzheimer's disease (AD), n = 34; corticobasal syndrome (CBS), n = 9] and validated in an independent sample of 164 dementia patients (bvFTD, n = 23; PPA, n = 82; AD, n = 38; CBS, n = 21) and 78 controls, who also completed the MMSE. Results: The M-ACE consists of 5 items with a maximum score of 30. Two cut-offs were identified: (1) ≤25/30 has both high sensitivity and specificity, and (2) ≤21/30 is almost certainly a score to have come from a dementia patient regardless of the clinical setting. The M-ACE is more sensitive than the MMSE and is less likely to have ceiling effects. Conclusion: The M-ACE is a brief and sensitive cognitive screening tool for dementia. Two cut-offs (25 or 21) are recommended. © 2014 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Published
- 2015
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