1. Clinical Characteristics and Functional Motor Outcomes of Enterovirus 71 Neurological Disease in Children.
- Author
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Teoh HL, Mohammad SS, Britton PN, Kandula T, Lorentzos MS, Booy R, Jones CA, Rawlinson W, Ramachandran V, Rodriguez ML, Andrews PI, Dale RC, Farrar MA, and Sampaio H
- Subjects
- Autonomic Nervous System Diseases diagnosis, Autonomic Nervous System Diseases epidemiology, Central Nervous System Viral Diseases diagnosis, Central Nervous System Viral Diseases epidemiology, Child, Preschool, Encephalitis, Viral diagnosis, Encephalitis, Viral epidemiology, Encephalitis, Viral etiology, Encephalomyelitis diagnosis, Encephalomyelitis epidemiology, Encephalomyelitis etiology, Enterovirus A, Human isolation & purification, Enterovirus Infections diagnosis, Enterovirus Infections epidemiology, Female, Follow-Up Studies, Humans, Infant, Magnetic Resonance Imaging, Male, New South Wales epidemiology, Paralysis diagnosis, Paralysis epidemiology, Paralysis etiology, Autonomic Nervous System Diseases etiology, Central Nervous System Viral Diseases etiology, Enterovirus A, Human pathogenicity, Enterovirus Infections complications
- Abstract
Importance: Enterovirus 71 (EV71) causes a spectrum of neurological complications with significant morbidity and mortality. Further understanding of the characteristics of EV71-related neurological disease, factors related to outcome, and potential responsiveness to treatments is important in developing therapeutic guidelines., Objective: To further characterize EV71-related neurological disease and neurological outcome in children., Design, Setting, and Participants: Prospective 2-hospital (The Sydney Children's Hospitals Network) inpatient study of 61 children with enterovirus-related neurological disease during a 2013 outbreak of EV71 in Sydney, Australia. The dates of our analysis were January 1, to June 30, 2013., Main Outcomes and Measures: Clinical, neuroimaging, laboratory, and pathological characteristics, together with treatment administered and functional motor outcomes, were assessed., Results: Among 61 patients, there were 4 precipitous deaths (7%), despite resuscitation at presentation. Among 57 surviving patients, the age range was 0.3 to 5.2 years (median age, 1.5 years), and 36 (63%) were male. Fever (100% [57 of 57]), myoclonic jerks (86% [49 of 57]), ataxia (54% [29 of 54]), and vomiting (54% [29 of 54]) were common initial clinical manifestations. In 57 surviving patients, EV71 neurological disease included encephalomyelitis in 23 (40%), brainstem encephalitis in 20 (35%), encephalitis in 6 (11%), acute flaccid paralysis in 4 (7%), and autonomic dysregulation with pulmonary edema in 4 (7%). Enterovirus RNA was more commonly identified in feces (42 of 44 [95%]), rectal swabs (35 of 37 [95%]), and throat swabs (33 of 39 [85%]) rather than in cerebrospinal fluid (10 of 41 [24%]). Magnetic resonance imaging revealed characteristic increased T2-weighted signal in the dorsal pons and spinal cord. All 4 patients with pulmonary edema (severe disease) demonstrated dorsal brainstem restricted diffusion (odds ratio, 2; 95% CI, 1-4; P = .001). Brainstem or motor dysfunction had resolved in 44 of 57 (77%) at 2 months and in 51 of 57 (90%) at 12 months. Focal paresis was evident in 23 of 57 (40%) at presentation and was the most common persisting clinical and functional problem at 12 months (observed in 5 of 6 patients), with 1 patient also requiring invasive ventilation. Patients initially seen with acute flaccid paralysis or pulmonary edema had significantly greater frequencies of motor dysfunction at follow-up compared with patients initially seen with other syndromes (odds ratio, 15; 95% CI, 3-79; P < .001)., Conclusions and Relevance: Enterovirus 71 may cause serious neurological disease in young patients. The distinct clinicoradiological syndromes, predominantly within the spinal cord and brainstem, enable rapid recognition within evolving outbreaks. Long-term functional neurological morbidity is associated with paresis linked to involvement of gray matter in the brainstem or spinal cord.
- Published
- 2016
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