1. Development of taste-masking microcapsules containing azithromycin by fluid bed coating for powder for suspension and in vivo evaluation.
- Author
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Dung, Pham-Thi-Phuong, Trinh, Thanh-Dat, Nguyen, Quoc-Hoai, Nguyen, Huu-Manh, Nguyen, Ngoc-Chien, Tran, Ngoc-Bao, Tran, Cao-Son, Nguyen, Thi-Hong-Ngoc, and Tung, Nguyen-Thach
- Subjects
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ETHYLCELLULOSE , *POWDER coating , *AZITHROMYCIN , *BIOAVAILABILITY , *GENERIC products , *BITTERNESS (Taste) , *GRANULATION - Abstract
This research aims to develop bitter taste-masking microcapsules containing azithromycin (AZI) by a simpler and familiar method, fluid-bed coating technology, in comparison with Zithromax®. Cores of microcapsules, AZI microparticles, were prepared by fluid-bed granulation, then taste-masking polymer was covered on by fluid-bed coating technique. Eudragit L100, Eudragit RL100, and ethyl cellulose in single and combined with Eudragit L100 and Eudragit E100 were used as taste-masking polymers. The obtained microcapsules were characterised by taste-masking ability, in vitro release, SEM, coating thickness, and coating efficiency. Combination of ethyl cellulose and Eudragit E100 (3:1) in coating thickness of 45.13 ± 2.12% w/w prevents AZI release from microcapsules below bitter taste threshold (1.78 ± 1.17 µg/ml). Bioavailability of powders containing AZI microcapsules and pH modulators (50 mg Na3PO4 and 35 mg Mg(OH)2) was not significantly different from the reference product (Zithromax®, Pfizer, New York, NY) in the rabbit model (p > 0.05). These results support the possibility of developing a generic product containing AZI. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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