1. The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples.
- Author
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Rodríguez-Rodríguez, Luis, Taib, Wan Rohani Wan, Topless, Ruth, Steer, Sophia, González-Escribano, María F., Balsa, Alejandro, Pascual-Salcedo, Dora, González-Gay, Miguel A., Raya, Enrique, Fernandez-Gutierrez, Benjamín, González-Álvaro, Isidoro, Bottini, Nunzio, Witte, Torsten, Viken, Marte K., Coenen, Marieke J. H., van Riel, Piet L. C. M., Franke, Barbara, den Heijer, Martin, Radstake, Timothy R. D. J., and Wordsworth, Paul
- Subjects
RHEUMATOID arthritis risk factors ,CONFIDENCE intervals ,EPIDEMIOLOGY ,GENETIC polymorphisms ,MEDICAL cooperation ,RESEARCH ,RESEARCH funding ,DATA analysis ,CASE-control method - Abstract
The article talks about the influence of PTPN22 R263Q polymorphism on the risk of rheumatoid arthritis (RA). Taq- Man 5'-allele discrimination assay was used to genotype the samples for the polymorphisms. The effect of the R263Q variant was analyzed with the effect of R620W, using Unphased and Stata 10 software. The study implied that the minor allele of the PTPN22 R263Q polymorphism had an additive effect on the risk of RA.
- Published
- 2011
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