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Contents North American zoos began using melengestrol acetate ( MGA) implants to control reproduction in wild felids in the mid-1970s. Research linking MGA and other progestin-based contraceptives to uterine and mammary pathology in canids as well as felids resulted in a shift to Gn RH agonist implants (Suprelorin®: deslorelin, Peptech Animal Health, Australia). However, a recent study revealed an association between Suprelorin® and uterine pathology in canids, but that pathology was not found in canids treated with oral megestrol acetate ( MA) for 2 weeks around the time of implant insertion to prevent the initial agonist stimulation phase. Thus, the AZA Wildlife Contraception Center ( WCC) currently recommends Suprelorin® plus the 2-week MA regimen for wild canids and felids. WCC research is now focusing on factors affecting Suprelorin® reversibility. [ABSTRACT FROM AUTHOR]