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2 results on '"HIV Antibodies biosynthesis"'

1. Detecting recent human immunodeficiency virus type 1 infection: why and how?

Author

Dobbs T and Parekh BS

Subjects
Education, Continuing, HIV Antibodies biosynthesis, HIV Antibodies blood, HIV Core Protein p24 blood, HIV Seropositivity epidemiology, HIV-1 genetics, HIV-1 immunology, HIV-1 isolation & purification, Humans, Immunoenzyme Techniques, Immunoglobulin G immunology, North America epidemiology, RNA, Viral blood, Sensitivity and Specificity, AIDS Serodiagnosis methods, HIV Seropositivity diagnosis
Published
2003

2. Geographic diversity of human immunodeficiency virus type 1: serologic reactivity to env epitopes and relationship to neutralization.

Author

Cheingsong-Popov R, Callow D, Beddows S, Shaunak S, Wasi C, Kaleebu P, Gilks C, Petrascu IV, Garaev MM, and Watts DM

Subjects
Africa, Amino Acid Sequence, Antibody Specificity, Antigenic Variation, Asia, Enzyme-Linked Immunosorbent Assay, Epitopes chemistry, Epitopes immunology, Europe, Gene Products, env chemistry, HIV Antibodies blood, Humans, Molecular Sequence Data, Neutralization Tests, North America, Peptides immunology, Predictive Value of Tests, Gene Products, env immunology, HIV Antibodies biosynthesis, HIV-1 immunology
Abstract

The antibody recognition of the major neutralization epitopes of human immunodeficiency virus type 1 (HIV-1) in 829 HIV-1-seropositive subjects from North America (106), Europe (241), Africa (342), and Asia (100) was investigated. Peptides derived from diverse published V3 loop sequences were used as antigen, and serum reactivity was detected by sensitive ELISAs. Antibody binding to peptides derived from the V3 loop sequence of HIV-1 isolates varies considerably depending on the geographic origin of the antibody and is associated with neutralization titer against homologous isolates. Serotype reactivity to peptides may be a simple and rapid approach to investigation of HIV-1 env diversity worldwide and may assist the choice of immunogen for development of future AIDS vaccines.

Published
1992
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