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• We modeled crash severity in run-off-the-road crashes. • Two mixed logit models were developed. • Results confirmed the contribution of roadway geometric design features to injuries. • The study provides valuable information to improve roadside design policies. Roadway departure (RwD) crashes, comprising run-off-road (ROR) and cross-median/centerline head-on collisions, are one of the most lethal crash types. According to the FHWA, between 2015 and 2017, an average of 52 percent of motor vehicle traffic fatalities occurred each year due to roadway departure crashes. An avoidance maneuver, inattention or fatigue, or traveling too fast with respect to weather or geometric road conditions are among the most common reasons a driver leaves the travel lane. Roadway and roadside geometric design features such as clear zones play a significant role in whether human error results in a crash. Method : In this paper, we used mixed-logit models to investigate the contributing factors on injury severity of single-vehicle ROR crashes. To that end, we obtained five years' (2010–2014) of crash data related to roadway departures (i.e., overturn and fixed-object crashes) from the Federal Highway Administration's Highway Safety Information System Database. Results : The results indicate that factors such as driver conditions (e.g., age), environmental conditions (e.g., weather conditions), roadway geometric design features (e.g., shoulder width), and vehicle conditions significantly contributed to the severity of ROR crashes. Conclusions : Our results provide valuable information for traffic design and management agencies to improve roadside design policies and implementing appropriately forgiving roadsides for errant vehicles. Practical applications : Our results show that increasing shoulder width and keeping fences at the road can reduce ROR crash severity significantly. Also, increasing road friction by innovative materials and raising awareness campaigns for careful driving at daylight can decrease the ROR crash severity. [ABSTRACT FROM AUTHOR]