1. Potent antifouling compounds produced by marine Streptomyces
- Author
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Xu, Ying, He, Hongping, Schulz, Stefan, Liu, Xin, Fusetani, Nobushino, Xiong, Hairong, Xiao, Xiang, and Qian, Pei-Yuan
- Subjects
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STREPTOMYCES , *BIOCIDES , *FOULING , *FOULING organisms , *ORGANOTIN compounds , *MARINE sediments , *EXTRACTS , *STRUCTURE-activity relationships , *PREVENTION - Abstract
Abstract: Biofouling causes huge economic loss and a recent global ban on organotin compounds as antifouling agents has increased the need for safe and effective antifouling compounds. Five structurally similar compounds were isolated from the crude extract of a marine Streptomyces strain obtained from deep-sea sediments. Antifouling activities of these five compounds and four other structurally-related compounds isolated from a North Sea Streptomyces strain against major fouling organisms were compared to probe structure–activity relationships of compounds. The functional moiety responsible for antifouling activity lies in the 2-furanone ring and that the lipophilicity of compounds substantially affects their antifouling activities. Based on these findings, a compound with a straight alkyl side-chain was synthesized and proved itself as a very effective non-toxic, anti-larval settlement agent against three major fouling organisms. The strong antifouling activity, relatively low toxicity, and simple structures of these compounds make them promising candidates for new antifouling additives. [Copyright &y& Elsevier]
- Published
- 2010
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