1. Fallopian Tube Mucosal Involvement in Cervical Gastric-type Adenocarcinomas: Report of a Series With Discussion of the Distinction From Synchronous In Situ Tubal Lesions.
- Author
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Rajendran S, Hussein Y, Park KJ, and McCluggage WG
- Subjects
- Adenocarcinoma chemistry, Adenocarcinoma surgery, Adult, Aged, Biomarkers, Tumor analysis, Biopsy, Fallopian Tube Neoplasms chemistry, Fallopian Tube Neoplasms surgery, Fallopian Tubes chemistry, Fallopian Tubes surgery, Female, Humans, Immunohistochemistry, Middle Aged, Mucous Membrane chemistry, Mucous Membrane surgery, Neoplasm Invasiveness, Northern Ireland, Ovarian Neoplasms secondary, United States, Uterine Cervical Neoplasms chemistry, Uterine Cervical Neoplasms surgery, Adenocarcinoma secondary, Fallopian Tube Neoplasms secondary, Fallopian Tubes pathology, Mucous Membrane pathology, Uterine Cervical Neoplasms pathology
- Abstract
Cervical gastric-type adenocarcinomas are aggressive non-human papillomavirus-related carcinomas with a propensity for extracervical spread, including unusual sites such as the omentum, peritoneum, and ovary. We report 7 cases of cervical gastric-type adenocarcinoma with fallopian tube involvement predominantly in the form of mucosal colonization without underlying invasion. As far as we are aware, this has not been previously described and this report adds to the literature regarding metastatic neoplasms, which may exhibit tubal mucosal involvement and mimic an in situ lesion at this site. In all cases, there was associated ovarian involvement and in 6 of 7 cases, there was endometrial colonization. We speculate that the fallopian tube (and ovarian) involvement is secondary to transuterine spread. Given the occasional occurrence of multifocal gastric-type glandular lesions (benign or malignant) involving different sites in the female genital tract, we discuss the distinction between synchronous independent and metastatic lesions.
- Published
- 2018
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