1. Immune Response to BNT162b2 in Solid Organ Transplant Recipients: Negative Impact of Mycophenolate and High Responsiveness of SARS-CoV-2 Recovered Subjects against Delta Variant.
- Author
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Cassaniti, Irene, Bergami, Federica, Arena, Francesca, Sammartino, Jose Camilla, Ferrari, Alessandro, Zavaglio, Federica, Curti, Irene, Percivalle, Elena, Meloni, Federica, Pandolfi, Laura, Pellegrini, Carlo, Turco, Annalisa, Seminari, Elena, Pattonieri, Eleonora Francesca, Gregorini, Marilena, Rampino, Teresa, Sarasini, Antonella, Lilleri, Daniele, and Baldanti, Fausto more...
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SARS-CoV-2 ,TRANSPLANTATION of organs, tissues, etc. ,COVID-19 vaccines ,IMMUNE response ,HUMORAL immunity - Abstract
The immunogenicity of severe acute respiratory syndrome 2 virus (SARS-CoV-2) vaccines in immunocompromised patients remains to be further explored. Here, we evaluated the immunogenicity elicited by complete vaccination with BNT162b2 vaccine in solid organ transplant recipients (SOTRs). A cohort of 110 SOTRs from Northern Italy were vaccinated with two doses of BNT162b2 mRNA vaccine and prospectively monitored at baseline and after 42 days. Both SARS-CoV-2 naïve and recovered subjects were included. Humoral response elicited by vaccination, including SARS-CoV-2 neutralizing antibodies (SARS-CoV-2 NT Abs), was evaluated; additionally, ex-vivo ELISpot assay was performed for the quantification of Spike-specific T-cell response. Results were compared with those obtained in a cohort of healthy subjects. In a subset of patients, humoral and T-cell responses against delta variant were also evaluated. Less than 20% of transplanted subjects developed a positive humoral and cell-mediated response after complete vaccination schedule. Overall, median levels of immune response elicited by vaccination were significantly lower with respect to controls in SARS-CoV-2 naïve transplant, but not in SARS-CoV-2 recovered transplanted patients. Additionally, a significant impairment of both humoral and cell-mediated response was observed in mycophenolate-treated patients. Positive delta-SARS-CoV-2 NT Abs levels were detected in almost all the SARS-CoV-2 recovered subjects but not in previously uninfected patients. Our study supports previous observations of a low level of seroconversion after vaccination in transplanted patients. [ABSTRACT FROM AUTHOR] more...
- Published
- 2021
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