1. The effect of pneumonia on mortality among patients hospitalized for acute stroke.
- Author
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Katzan IL, Cebul RD, Husak SH, Dawson NV, and Baker DW
- Subjects
- Acute Disease, Aged, Aged, 80 and over, Black People statistics & numerical data, Cohort Studies, Comorbidity, Disease Susceptibility epidemiology, Female, Frail Elderly statistics & numerical data, Hospital Mortality, Humans, Incidence, Logistic Models, Male, Multivariate Analysis, Ohio epidemiology, Risk, Risk Assessment, Severity of Illness Index, White People statistics & numerical data, Black or African American, Inpatients statistics & numerical data, Pneumonia mortality, Stroke mortality
- Abstract
Objective: To determine the effect of pneumonia on 30-day mortality in patients hospitalized for acute stroke., Methods: Subjects in the initial cohort were 14,293 Medicare patients admitted for stroke to 29 greater Cleveland hospitals between 1991 and 1997. The relative risk (RR) of pneumonia for 30-day mortality was determined in a final cohort (n = 11,286) that excluded patients dying or having a do not resuscitate order within 3 days of admission. Clinical data were obtained from chart abstraction and were merged with Medicare Provider Analysis and Review files to obtain deaths within 30 days. A predicted-mortality model (c-statistic = 0.78) and propensity score for pneumonia (c-statistic = 0.83) were used for risk adjustment in logistic regression analyses., Results: Pneumonia was identified in 6.9% (n = 985) of all patients and in 5.6% (n = 635) of the final cohort. The rates of pneumonia were higher in patients with greater stroke severity and features indicating general frailty. Unadjusted 30-day mortality rates were six times higher for patients with pneumonia than for those without (26.9% vs 4.4%, p < 0.001). After adjusting for admission severity and propensity for pneumonia, RR of pneumonia for 30-day death was 2.99 (95% CI 2.44 to 3.66), and population attributable risk was 10.0%., Conclusion: In this large community-wide study of stroke outcomes, pneumonia conferred a threefold increased risk of 30-day death, adding impetus to efforts to identify and reduce the risk of pneumonia in patients with stroke.
- Published
- 2003
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