1. Herpes simplex virus: a possible etiologic agent in some gastroduodenal ulcer disease.
- Author
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Kemker BP Jr, Docherty JJ, De Lucia A, Ruf W, and Lewis RD
- Subjects
- Adult, Aged, Biopsy, Duodenal Diseases complications, Duodenal Diseases pathology, Endoscopy, Digestive System, Female, Follow-Up Studies, Herpes Simplex complications, Herpes Simplex pathology, Humans, Male, Middle Aged, Nucleic Acid Hybridization, Ohio epidemiology, Peptic Ulcer epidemiology, Risk Factors, Stomach Diseases complications, Stomach Diseases pathology, DNA, Viral analysis, Duodenal Diseases microbiology, Herpes Simplex microbiology, Peptic Ulcer etiology, Stomach Diseases microbiology
- Abstract
There is increasing evidence that the herpes simplex virus may account for some gastric ulcer disease. To examine this possibility, 62 tissue biopsies from 21 patients were obtained during esophagogastroduodenoscopy for gastroduodenal ulcer disease and from one operative specimen during the procedure for perforation of a gastric ulcer. The samples were collected from the base and rim of the ulcer, as well as from apparently healthy tissue adjacent to the lesion. When the DNA was extracted from these tissues and hybridized to a herpes simplex virus-specific DNA probe, positive results were obtained with 9.5 per cent (2 out of 21) of the patients with benign ulcers. Positive signals were obtained only with ulcer-associated tissues and never with healthy tissue. Hybridization also occurred with DNA from one ulcerative carcinoma in the study. These data suggest that a subset of ulcer disease may be caused by herpes simplex virus or that this virus may be secondarily associating with these lesions.
- Published
- 1992