1. Sodium oxybate in the treatment of binge eating disorder: An open-label, prospective study.
- Author
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McElroy, Susan L., Guerdjikova, Anna I., Winstanley, Erin L., O'Melia, Anne M., Mori, Nicole, Keck, Paul E., and Hudson, James I.
- Subjects
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ANALYSIS of variance , *BULIMIA , *CLINICAL trials , *COMPUTER software , *LONGITUDINAL method , *CLASSIFICATION of mental disorders , *REGRESSION analysis , *STATISTICAL hypothesis testing , *DATA analysis , *GAMMA-hydroxybutyrate , *BODY mass index , *REPEATED measures design , *THERAPEUTICS - Abstract
Objective: To assess preliminarily the effectiveness of sodium oxybate in binge eating disorder. Method: This was an open-label, prospective, 16-week, flexible dose study of sodium oxybate in binge eating disorder. The primary outcome was binge eating episode frequency. Results: Twelve individuals received sodium oxybate, 10 completed at least one postbaseline evaluation, and five completed the study. Mean dose at endpoint was 7.1 (2.0) g/day. Sodium oxybate was associated with significant reductions in frequency of binge days and binge episodes, as well as measures of clinical severity, eating pathology, obsessive-compulsive symptoms, food cravings, body mass index, and body weight. Nine participants had remission of binge eating and five lost ⩾5% of their baseline weight; all five of the latter participants had remission of binge eating. Discussion: In this open-label trial, sodium oxybate was effective in binge eating disorder, but associated with high a discontinuation rate. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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