1. A family with multiple instances of definite, probable and possible early-onset Alzheimer's disease.
- Author
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Karlinsky H, Madrick E, Ridgley J, Berg JM, Becker R, Bergeron C, Hodgkinson S, Percy ME, and McLachlan D
- Subjects
- Adult, Aged, Alzheimer Disease diagnosis, Alzheimer Disease psychology, Chromosome Aberrations diagnosis, Chromosome Aberrations psychology, Chromosome Disorders, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Ontario, Pedigree, Alzheimer Disease genetics, Chromosome Aberrations genetics, Genes, Dominant genetics
- Abstract
A family with a multigenerational history of proven or suspected early-onset Alzheimer's disease (AD) consistent with autosomal-dominant inheritance is described. To date, the pedigree comprises five generations in which there are 13 known affected individuals. The mean age of onset of cognitive deficits in those for whom data are available (n = 11) is 47.6 (s.d. 3.0) years and the mean age of death (n = 10) is 58.8 (s.d. 4.0) years. The variability in the extent and quality of available data illustrates the diagnostic difficulties encountered in ascertaining such an extended pedigree, and the need for caution in interpreting the evidence.
- Published
- 1991
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