1. A new family of sesterterpenoids isolated around the Pacific Rim.
- Author
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Shirley HJ, Jamieson ML, Brimble MA, and Bray CD
- Subjects
- Animals, Anti-HIV Agents chemistry, Anti-HIV Agents pharmacology, Aquatic Organisms chemistry, Biological Products chemistry, Biological Products isolation & purification, Cell Differentiation drug effects, Cyclic AMP metabolism, Drug Evaluation, Preclinical methods, Humans, Molecular Structure, Pacific Ocean, Porifera chemistry, Sesterterpenes pharmacology, Stem Cells drug effects, Biological Products pharmacology, Sesterterpenes chemistry, Sesterterpenes isolation & purification
- Abstract
Covering: 2009 up to the end of 2017 There has been a recent eruption in the number of known marine sesterterpenoids which have been isolated from Pacific Rim marine organisms. These compounds have novel and unusual structures that exhibit incredibly potent and varied bioactivities. This review details the isolation, biological testing and prospects for this exciting new family with discussion of their potential biogenetic origins.
- Published
- 2018
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