1. Antibiotic Dixiamycins from a Cold-Seep-Derived Streptomyces olivaceus .
- Author
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Jin E, Li H, Liu Z, Xiao F, and Li W
- Subjects
- Anti-Bacterial Agents isolation & purification, China, Drug Resistance, Multiple, Bacterial, Geologic Sediments microbiology, Microbial Sensitivity Tests, Molecular Structure, Pacific Ocean, Sesquiterpenes isolation & purification, Anti-Bacterial Agents pharmacology, Seawater microbiology, Sesquiterpenes pharmacology, Streptomyces chemistry
- Abstract
Two new ( 1 and 2 ) along with six known ( 3 - 8 ) dixiamycins were isolated from the culture broth of a cold-seep-derived actinomycete, Streptomyces olivaceus OUCLQ19-3. Structures of the isolated compounds were elucidated based on extensive MS and NMR spectroscopic analyses together with ECD calculations. In the antibacterial test, compounds 1 - 8 exhibited notable growth inhibitions against a panel of multi-drug-resistant (MDR) strains with MIC values of 0.78-6.25 μg/mL, among which 1 , 2 , and 5 - 7 were more potent than the positive control tetracycline.
- Published
- 2021
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