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Backgroud: Pregnancy is a state of increased metabolic demand, and poor maternal nutrition can exacerbate these changes, potentially increasing the risk of cardiometabolic disorders.This study is significant as it investigates the effect of high energy nutritional supplements on cardio metabolic risk markers in underweight primigravidas., Methodology: A single blinded randomized controlled trial was conducted from April 2018- August 2019 among the Pakistani tertiary care facilities of Khyber Pakhtunkhwa. A total of thirty six participants were randomized into two groups receiving either high energy nutritional supplement 'MAAMTA' or Placebo. They were instructed to take Placebo/Supplement alongside to their regular prenatal care and food from their first antenatal visit till a week postnatally. Anthropometric measurements and blood samples for biochemical parameters insulinlevels, fasting blood glucose & lipid profile were taken at baseline visit, between 16 and 20 weeks gestation and a post natal visit., Results: The two-way repeated measures ANOVA showed that there was a highly significant time effect on participant's Insulin level (F (1.8, 53.6) = 10.64, P < 0 0.000, ηp 2  = 0.269). A highly significant time effect on participant's insulin resistance (F (2, 68) = 8.116,P < 0 0.001, ηp 2  = 0.193) was also observed. There was a highly significant time effect on participant's LDL level as well (F (2, 68) = 11.82, P < 0 0.000, ηp 2  = 0.258)., Conclusion: Supplementation with high energy nutritional supplements may improve insulin levels and insulin sensitivity in underweight primigravidas., Trial Registration: https://www., Clinicaltrials: gov ClinicalTrials.gov Identifier: ISRCTN 10088578. Registered on 27 March 2018. https://www.isrctn.com/ISRCTN10088578 ., (© 2024. The Author(s).)

To evaluate the efficacy of ginger, garlic, lemon, apple cider vinegar and honey mixture on cardio metabolic risk factors in patients with metabolic syndrome. A double blinded Randomized control was conducted in OPD of Military Hospital, Pakistan, from 30 June 2018 to 30 Sep 2018. Eighty eight participants with positive cardio metabolic risk factors between 30 to 65 years were randomly selected and allocated into experimental and placebo Group. Equal quantities of garlic, ginger, lemon juice and apple cider vinegar were boiled at 70°C for 15 minutes. At the start, after 45th days and after 90th day anthropometric measurements, blood pressure, lipid profile and blood sugar level. Blood pressure and fasting blood sugar, TC, LDL, HDL were significantly decreased in experimental group from 155 to 132mg/dl [P<0.03]. While no remarkable change has been detected on anthropometric measurements. The findings of the study concluded that ginger, garlic, lemon, apple cider vinegar and honey mixture exhibited anti-hyperlipidemia, antihypertensive and anti-diabetic properties, while no significant change was observed in BMI and waist to hip ratio. [ABSTRACT FROM AUTHOR]