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The wise use of water resources is the dire need of the day due to the alarming situation of water crisis. Management Allowed Depletion (MAD) level irrigation technique is used to enhance crop yield as well as the precise use of water. The present study was designed to investigate the optimum MAD level (when to irrigate) at which tuber yield and quality did not deteriorate significantly. Four different MAD levels were scheduled i.e., irrigation applied when MAD0 = 0%, MAD20 = 20%, MAD35 = 35%, and MAD50 = 50% of available soil water depleted from the soil at Water Management Research Center, University of Agriculture, Faisalabad-Pakistan during the two successive winter growing seasons (2014-15 and 2015-16). Data of different physico-chemical properties and yield of potato tubers were gathered under the Randomized Complete Block Design (RCBD) and set into standard statistical techniques. Results revealed that physical parameters (i.e., length, thickness, diameter, weight, and actual volume) of potato tubers were significantly affected by the different MAD levels, while MAD35 was at par with other irrigation schedules. Different MAD levels didn't show significant effects on some of the physico-chemical properties (i.e., particle density, porosity, specific gravity, tuber starch content, and total soluble solids) of potato tubers, and revealed that these traits are entirely genetic based. While tuber size percentage and yield are significantly affected by the different MAD levels. The maximum yield (i.e., 15.52, 16.76 in tons acre-1) and crop water productivity (i.e., 14.19 and 14.64 in kg m-3) were also observed at MAD35 during both years. In nutshell, results revealed that both advanced and delayed irrigation practices severely affect the physical parameters, yield as well as to some extent physico-chemical traits of potato tubers. Therefore, 35% MAD level schedule is the optimum one and recommended for potato cultivation under bed sowing. [ABSTRACT FROM AUTHOR]

One of the major concerns in Flood Frequency Analysis (FFA) is to predict floods of high magnitude for larger return periods. Magnitudes of smaller floods behave as nuisance in the estimation of larger floods. In this study, to avoid the unnecessary effect due to smaller observations, we implemented the technique of left censoring. The primary objective of this study is to see the efficacy of censoring, by comparing Regional Flood Frequency Analysis (RFFA) using Partial Linear Moments (PLM) for censored samples with RFFA using Linear Moments (LM) for uncensored samples of annual peak flows observed at ten stations of Indus Basin in Pakistan. After fulfillment of fundamental assumptions of randomness, independence, homogeneity, and stationarity, a Grubbs-Beck (GB) test for outlier detection is applied to the samples from all stations. For further analysis, Discordancy measure shows that none of the site is discordant and all ten stations would be retained for further investigation. On the basis of geographical closeness, stream hydrology and morphology of Indus basin, a single homogenous region is proposed and testified by the heterogeneity standards. The best fit distribution is selected by implying the Z-statistic (goodness of fit test base on LM) and L-Moments Ratio Diagram (LMRD). Generalized Pareto Distribution (GPA) distribution under PLM while Generalized Normal Distribution (GNO) under LM is selected as the reasonable choice for design flood estimation. Monte Carlo simulation experiment is performed to check the efficacy of PLM over LM through Root Means Square Error (RMSE) and bias. These accuracy measures indicated the outperformance of censored samples under PLM to uncensored samples under LM. [ABSTRACT FROM AUTHOR]

The existence of natural radioactivity in phosphate fertilizers originates from the rock phosphate that is used as a feed stock for the manufacturing of various types of phosphate fertilizers. Gamma ray activity mass concentrations have been determined in phosphate rock and fertilizer samples collected from different fertilizer manufacturing factories and suppliers in Pakistan. The technique of gamma ray spectrometry was applied using a HPGe (high purity germanium) gamma ray detector coupled with a personal computer (PC) based multichannel analyzer (MCA). The specific activity values of 40K, 226Ra, and 232Th were widely distributed in the rock and fertilizer samples. Activity mass concentrations of 238U (226Ra) in the rock phosphate from Jordan and Pakistan were 428 ± 11 and 799 ± 10 Bq kg-1, respectively, and that in the triple-superphosphate fertilizer was 701 ± 21 Bq kg-1, which was greater than the average values of 238U (226Ra) for other types of fertilizers under study. The concentrations of 40K and 232Th were of the order of background level on the Earth's crust. Chemical analysis for concentration of different constituents in rock phosphate was also carried out. The higher the concentrations of P2O5 and K2O were, the higher the specific activities of 226Ra and 40K were, respectively, in the rocks under study. The amount of radioactivity in the rock phosphate is a source of continuous exposure to radiation, which varies widely depending upon the origin and grade of rock; therefore, radiation dose rate has been estimated. The values of dose rate and other derived quantities were many folds larger than the limits specified for those quantities. [ABSTRACT FROM AUTHOR]

Abstract: Natural radioactivity originates from extraterrestrial sources as well as from primordial radioactive elements in the earth crust. The amount of radioactivity in soil varies widely and is a source of continuous exposure of human beings to terrestrial radioactivity that depends upon the type of soil and its uses. For the investigation of radioactivity in barren and cultivated soil, an area of about 80ha of saline soil was selected in Pakka Anna near the city of Faisalabad in the Punjab province of Pakistan. Activity concentration levels due to 40K, 137Cs, 226Ra and 232Th were measured with HPGe detector in 250 saline soil samples collected at a spacing of about 8ha at a depth of 0–25cm with intervals of 5cm depth. Activity concentration ranges of the concerned radionuclides for both of the soils were as follows: 40K, for barren and cultivated saline soil was 499–604 and 563–, respectively; 137Cs, 3.57–3.63 and 1.98–; 226Ra, 24–29 and 27–, and 232Th, 49–54 and 46–. Gamma dose was estimated using the activity to dose rate conversion factors. The measured activity concentrations and the estimated radiation dose were found to be lying within the range specified in the 2000 report of UNSCEAR. Chemical analysis for Na, Ca and Mg was also carried out along with the measurement of electrical conductivity and pH of soil samples. [Copyright &y& Elsevier]

Rapid urbanization worldwide, poses numerous environmental challenges between escalating land use land cover (LULC) changes and groundwater quality dynamics. The main objective of this study was to investigate the dynamics of groundwater quality and LULC changes in Sargodha district, Punjab, Pakistan. Groundwater hydrochemistry reveals acceptable pH levels (<8) but total dissolved solids (TDS), electrical conductivity (EC) and HCO 3 - showed dynamic fluctuations by exceeding WHO limits. Piper diagrams, indicated dominance by magnesium and bicarbonate types, underscoring the influence of natural processes and anthropogenic activities. Major ion relationships in 2010, 2015, and 2021 showed a high correlation (R2 > 0.85) between Na + and Cl - , suggesting salinization. whereas, the poor correlation (<0.17) between Ca 2+ and HCO 3 - does not support calcite dissolution as the primary process affecting groundwater composition. The examination of nitrate contamination in groundwater across the years 2010, 2015, and 2021 was found to be high in the municipal sewage zone, suggesting a prevailing issue of nitrate contamination attributed to urban activities. The Nitrate Pollution Index (NPI) reveals a concerning trend, with a higher proportion of samples classified under moderate to high pollution categories in 2015 and 2021 compared to 2010. The qualitative assessment of nitrate concentration on spatiotemporal scale showed lower values in 2010 while a consistent rise from 2015 to 2021 in north-east and western parts of district. Likewise, NPI was high in the north-eastern and south-western regions in 2010, then reduced in subsequent years, which may be attributed to effective waste management practices and alterations in agricultural practices. The health risk assessment of 2010 indicated Total Health Hazard Quotient (THQ) within the standard limit, while in 2015 and 2021, elevated health risk was observed. This study emphasizes the need to use multiple approaches to groundwater management for sustainable land use planning and regulations that prioritize groundwater quality conservation., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Groundwater contamination with arsenic (As) is a significant concern in Pakistan's Punjab Province. This study analyzed 69 groundwater samples from Faisalabad, Gujranwala, Lahore, and Multan to understand hydrogeochemistry, health impacts, contamination sources, and drinking suitability. Results revealed varying as concentrations across districts, with distinctive cation and anion orders. Faisalabad exhibited Na +  > Mg 2+  > Ca 2+  > K +  > Fe 2+ for cations and SO 4 2-  > Cl -  > HCO 3 -  > NO 3 -  > F - for anions. Gujranwala showed Na +  > Ca 2+  > Mg 2+  > K + for cations and HCO 3 -  > SO 4 2-  > Cl -  > NO 3 -  > F - for anions. In Lahore, demonstrated: Na +  > Ca 2+  > Mg 2+  > Fe > K + for cations and HCO 3 -  > SO 4 2 -  > Cl -  > NO 3 -  > F - for anions. Multan indicated K +  > Ca 2 +  > Mg 2 +  > Na +  > Fe for cations and HCO 3 -  > SO 4 2-  > Cl -  > F -  > NO 3 - ) for anions. Hydrochemical facies were identified as CaHCO 3 and CaMgCl types. Principal Component Analysis (PCA), highlighted the influence of natural processes and human activities on groundwater pollution. Water Quality Index (WQI) result reveal that most samples met water quality standards. The carcinogenic risk values for children exceeded permissible limits in all districts, emphasizing a significant cancer risk. The study highlights the need for rigorous monitoring to mitigate (As) contamination and protect public health from associated hazards., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

This paper investigates the long-run and short-run relationship between money supply and inflation in Pakistan, utilizing annual data spanning from 1981 to 2021. The key objective is to assess the impact of monetary policy, specifically money supply, on inflation dynamics in the country. To achieve this, the Autoregressive Distributed Lag (ARDL) bounds testing approach is employed, which is suitable for analyzing cointegration among variables with mixed integration orders. The results reveal both short and long-run cointegration between inflation, money supply, unemployment, and interest rates. Notably, unemployment demonstrates a negative correlation with inflation, while money supply and interest rates exhibit a positive relationship. These findings underscore the importance of dedicated policy measures to manage inflation effectively. The paper concludes by recommending the establishment of a policy implementation body and collaboration between the government and the central bank to ensure financial stability and control inflation through well-calibrated monetary and fiscal policies., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Stylianou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

The literature review lacks empirical studies on the role of big data analytics (BDA) and green technological innovation capabilities (GTICs) in promoting the sustainable performance of the manufacturing industry. The primary objective of this study is to examine the role of BDA-technology capability, GTIC, and environmental orientation toward green production and sustainable firm performance. Moreover, this research paper investigates the mediating role of green production and green competitive advantage and the moderating role of corporate reputation and supply chain innovativeness. Primary data was collected from Pakistani manufacturing firms through the survey method. Structural equation modeling was applied to measure and verify the relationship of proposed hypotheses. Empirical findings show BDA technology capability, GTIC, and environmental orientation positively contribute to green production. Moreover, green production helps achieve a green competitive advantage, and green competitive advantage positively influences sustainable firm performance. Furthermore, mediating role of green production and green competitive advantage and moderating role of corporate reputation and supply chain innovativeness was also confirmed. This study contributes by developing a comprehensive model showing the relationship between organizational capabilities, BDA technology capability, GTIC, and sustainable firm performance by considering potential mediators and moderators. Thus, this research suggests enhancing green production and sustainable firm performance through adopting BDA technology capability and GTIC by Pakistani manufacturing firms., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Reducing energy usage and promoting energy management practices remain hot issues in the construction sector. Construction firms are not interested to adopt energy conservation and management practices in their projects. Despite the successful integration of energy management practices in developed nations, their adaptability in developing countries, especially in Pakistan, is at a slow pace. Therefore, drivers to energy management practices need to be realized for its adoption. Based on this, the current study intends to evaluate the drivers of energy management practices adopted in the construction sector of Pakistan by using a four-stage methodology. Fuzzy Delphi method (FDM), interpretive structural modeling (ISM), and Matrice d'Impacts Croises Multiplication Appliques a un Classement (MICMAC) analysis were integrated with prioritizing essential drivers. Increased tax imposition on construction companies for energy usage and pollution contribution, promotion of investment subsidies for energy efficiency technologies, and increased enforcement of government rules and regulations regarding on-site energy management practices arose as significant drivers to adoption of energy management practices in the construction sector of Pakistan. These results will be helpful for policymakers to develop effective policies for integrating energy management practices in the construction sector. This study contributes significantly by developing a novel model of drivers affecting EMP adoption in the Pakistani construction sector. Further research might be expanded to other developing countries to validate current results., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

The COVID-19 pandemic, was first identified in Wuhan, China, has had a drastic effect on the world economy and compelled governments to enforce lockdown in territories. However, lockdown is destroying the world economy badly as well as the physical and mental health of people. Therefore, governments must develop Lockdown Relaxation Strategies (LRS) to overcome the negative consequences of lockdown in Pakistan. Identifying LRS is important for public health and economic restoration. Therefore, this work is an initial attempt to develop LRS in a developing country - Pakistan, and prioritize LRS through a novel ISM-MICMAC approach. By taking response from experts, results show that implementation of smart lockdowns in affected areas, meeting minimum criteria of public health standards, limited operations of public transportation are the most important strategies. Results provide a strategic guideline for governments to take necessary measures and allocate resources appropriately.

The objective of this study was to conduct a reliability analysis on photovoltaic (PV) modules from the oldest PV installation site in Pakistan. Four sets of modules; Type A & B (30 years old), Type C (10 years old), and Type D (35 years old) were identified for this analysis. It has been observed that modules have shown degradation after working for a good number of years in the field. Comparing with nameplate data (available for Type B & C only), a drop of 28.68% and 2.99 percentage points (pp) was observed in the output power (Pmax) and efficiency (Eff.) respectively for Type B, while a drop of 22.21% and 4.05 pp was observed in Pmax and Eff. respectively for Type C. A greater drop in ISC and Pmax was observed in Type B, which is attributed to severe browning of EVA in them. While the greater drop in Pmax, in case of Type C, is attributed to the poor quality of materials used. Amongst the different defects observed, the junction box defects which include cracking and embrittlement, etc., and backsheet defects which include discoloration, delamination and cracking, etc. were found in all four types of modules. Other defects include browning of EVA, observed in Type B and D, and corrosion of frame and electrical wires, found in Type A, B, and D. This first-ever study will provide valuable information in understanding the degradation mechanism and henceforth, improving the long term reliability of PV modules in the humid-subtropical conditions of Pakistan., Competing Interests: The authors have declared that no competing interests exist.

Aflatoxins (AFs) are secondary metabolites toxic to humans as well as animals. The environmental conditions, conventional agricultural practices, and illiteracy are the main factors which favor the production of AFs in food and feed. In the current study 744 samples of vegetable seeds and oils (soybean, sunflower, canola, olive, corn, and mustard) were collected and tested for the presence of aflatoxin B 1 (AFB 1 ) and total AFs. Liquid-liquid extraction was employed for the extraction of AFs from seeds and oil samples. Reverse phase high performance liquid chromatography equipped with fluorescence detection was used for the analysis. The results have shown that 92 (56.7%) samples of imported and 108 (57.0%) samples of local edible seeds were observed to be contaminated with AFs. All samples of edible seeds have AFB 1 levels greater than the proposed limit set by the European Union (EU, 2 µg/kg) and 12 (7.40%) samples of imported seeds and 14 (7.40%) samples of local seeds were found in the range ≥ 50 µg/kg. About 78 (43.3%) samples of imported edible oil and 103 (48.3%) sample of local edible oil were observed to be positive for AFs. Furthermore, 16 (8.88%) and six (3.33%) samples of imported vegetable oil have levels of total AFs in a range (21-50 µg/kg) and greater than 50 µg/kg, respectively. The findings indicate significant differences in AFs levels between imported and local vegetable oil samples (t = 22.27 and p = 0.009) at α = 0.05 and a significant difference in AFs levels were found between vegetable seeds and oil samples (t = -17.75, p = 0.009) at α = 0.05. The highest dietary intake was found for a local sunflower oil sample (0.90 µg/kg/day) in female individuals (16-22 age group). The results have shown considerably high levels of AFB1 and total AFs in seeds and oil samples and emphasise the need to monitor carefully the levels of these toxic substances in food and feed on regular basis.

Fish is consumed as a rich and cheaper source of white meat and proteins all over the world. Fish farming is the leading source of income generation throughout the world. The present research study was conducted with aims to investigate the ecto and endo parasitic fauna of S. plagiostomus (snow trout) in River Swat. A total of 96 fish samples were collected on monthly basis from July-2018 to February-2019, from upper, middle and lower reaches. Fish samples were collected with the help of cast net, hand net and fishing rods. Local fishermen and experts help were also sought out for fish collection. 61 out of 96 fishes were found infected by helminth parasites. The total prevalence and intensity of 63.54% and 2.90 was observed respectively during data analysis. Highest monthly prevalence of 83.33% was recorded during July and August, while lowest prevalence of 33.33% was noted during February. Five species of helminths parasites were detected from S. plagiostomus, of which two were trematodes (Rhabdochona shizothoracis and Rhabdochona species), one species of Monogenia (Diplozoon paraddoxum), one species of Cestodes (Nippotaenia species), and one species of Acanthocephalan (Neoechynorhynchus devdevi). Highest parasite wise prevalence, intensity and relative density of 21.87%, 4.09 and 0.895 was noted for R. schizothoracis while the lowest prevalence, intensity and relative density of 4.16%, 1.25 and 0.052 was noted for N. devdevi. Highest infection of 76.08% was observed in adults host while lowest, 40% infestation rate was observed in young fish samples. 73.68% prevalence was observed in female hosts while only 56.90% prevalence was observed in male individuals. Higher infection (83.33%) was noticed during summer season, while lowest infection (44.44%) was observed during winter season. Similarly 71.79% fishes were found infected that were collected from lower reaches of the River Swat than the fish samples collected from upper reaches (52%).

Objective: To assess work-life balance among medical residents at a tertiary hospital., Methods: The cross-sectional study was conducted from September to December 2016 at a private-sector tertiary care hospital in Karachi, and comprised medical residents working at the facility. A standardised, self-administered questionnaire was developed on the basis of Canadian Mental Health quiz and a study in literature. The questions aimed at assessing satisfaction with work as well as emotional and personal life of residents in various medical and surgical specialties. SPSS 20 was used for data analysis., Results: Of the 275 residents, 129(46.9%) were males and 146(53.1%) were females. The overall mean age was 28.19±2.194 years. Of the total, 13(4.7%) participants thought they had work-life balance; 165(60%) felt their job had negatively affected their private lives; 118(42.9%) felt worn out; 109(39.6%) expressed moderate dissatisfaction with work-related factors; 119(43.3%) were dissatisfied with life outside work; and 93(33.8%) were dissatisfied their health., Conclusions: There was minimal work-life balance among the residents.

The present study was conducted to investigate the concentrations of potential toxic metals (PTMs) in agricultural soil (n = 25) and their bioaccumulation in wheat crop (n = 25) collected from alongside the Kurram River, Pakistan. The highest concentrations of Cd, Cr, Cu, Fe, Mn, Ni, Pb, and Zn in soil samples were 0.16, 19.5, 14.7, 46.5, 13.5, 14.5, 14.0, and 19.7 mg kg -1 , respectively. In the edible tissues of cultivated wheat crop, the highest concentrations of Cd, Cr, Cu, Fe, Mn, Ni, Pb, and Zn were 0.15, 10.00, 8.75, 22.25, 11.00, 11.25, 10.50, and 7.50 mg kg -1 , respectively. The selected PTM concentrations in soil samples were observed within their respective permissible limits set by the Food and Agriculture Organization (FAO) and State Environmental Protection Administration (SEPA) China, while in wheat crops, the Cr and Pb concentrations were above the permissible limits of both FAO and SEPA China. The results showed that the orders of PTMs were Fe > Zn > Cr > Cu > Ni > Pb > Mn in soil and Fe > Ni > Mn > Pb > Cr > Cu > Zn in wheat. The highest PTM concentrations were reported in the sample collected near dumping sites. The results of different soil pollution indices including geo-accumulation index (Igeo), contamination factor (CF), and enrichment factor (EF) indicated that the soil of the study area was moderately to severely contaminated. The ADI values of wheat crops were less than 1, while the HQ varied among different PTMs with the highest value of 2.118 for Pb, and the lowest for Zn (0.007). The results indicated that anthropogenic intervention has made a substantial contribution to soil contamination with PTMs and subsequent uptake by wheat, which may exert potential human health risk.

A comprehensive study was conducted to appraise the concentrations of 30 endocrine disrupting pesticides (EDPs) in soil and vegetable samples collected from Khyber Pakhtunkhwa, Pakistan. The sum of 30 EDPs (Σ 30 EDPs) ranged from 192 to 2148 μg kg -1 in the collected soils. The selected EDP concentrations exceeded their respective limits in most of the tested soils and showed great variation from site to site. Similarly, high variations in Σ 30 EDP concentrations were also observed in vegetables with the highest mean concentration in lettuce (28.9 μg kg -1 ), followed by radish (26.6 μg kg -1 ), spinach (25.7 μg kg -1 ), onion (16.2 μg kg -1 ), turnip (15.6 μg kg -1 ), and garlic (14.7 μg kg -1 ). However, EDP levels in all studied vegetables were within FAO/WHO limits. The mean bioconcentration factor values were observed < 1 for all the studied vegetables. The health risk assessment revealed that the incremental lifetime cancer risk (ILCR) of Σ 30 EDPs associated with vegetable ingestion was below the acceptable risk level (1 × 10 -6 ), showing no cancer risk to local inhabitants. However, exposure to endocrine disruptor and probable carcinogen heptachlor epoxide poses a potential non-cancer risk (hazard quotient (HQ > 1)) to children through vegetable consumption. The presence of banned EDPs in soils and vegetables of the study area indicates the stability of these legacy chemicals in the environment from over usage in the past or illegal current application for agricultural purposes. Graphical abstract.

Toxoplasmosis is a major zoonotic disease of warm-blooded animals caused by Toxoplasma gondii. Cats are the only definitive host and they excrete environmentally resistant T. gondii oocysts in their faeces. Coproscopy was used to detect oocysts of enteric coccidians and then Copro-PCR was employed to test specifically for T. gondii in 470 cat samples. The prevalence of T. gondii oocysts was 2.3% (11/470) based on PCR. We observed 15 (3.2%) of 470 samples positive for coccidian oocysts by microscopy. The presence of Copro-DNA of T. gondii was found significantly higher (p<0.05) in males than females. We tested 11 samples of T. gondii oocysts in which 9 samples were from coccidian oocysts positive samples and 2 samples from negative faecal samples. Our results showed that PCR is the reliable method for the detection of faecal oocysts of T. gondii in cats as compared to microscopy. As per our knowledge, ours is first study for Copro-PCR prevalence of cats' T. gondii oocysts excretion in Pakistan.

Background: Neurorehabilitation is an important aspect of continuing care for neurosurgical patients with functional disability. In developing countries, where formal home nursing frequently is unavailable, ensuring care after discharge is a difficult task. Training attendants to provide nursing care is an alternate option. In this study, we compared the outcomes of patients nursed by family members versus those looked after by a professional nurse., Methods: This was a retrospective observational study conducted at the Aga Khan University Hospital Karachi. The study consisted of 2 groups. Group 1 (consisting of patients cared for by a professional nurse) included 94 patients and group 2 (patients cared for by family members) included 102. All these patients had activity of daily living score of ≥3. Glasgow Outcomes Scale score, time to decannulation, development/worsening of bedsores, and mortality were recorded and compared between the groups at follow-up., Results: The study included 196 patients. Traumatic brain injury was the most common diagnosis. Nursing requirements were similar between the 2 groups and included tracheostomy care, percutaneous endoscopic gastrostomy tube care, peripherally inserted central catheter line care, care of patients with no bone flap, and log-rolling. The outcomes of the 2 groups were comparable and included bedsore development/worsening of grade, Glasgow Outcomes Scale score at follow-up, time to decannulation, and 30-day mortality., Conclusions: There was no statistically significant difference in outcomes of patients nursed by family members compared with the patients looked after by professional nurses., (Copyright © 2016 Elsevier Inc. All rights reserved.)

Hepatitis E and Hepatitis A virus both are highly prevalent in Pakistan mainly present as a sporadic disease. The aim of the current study is to isolate and characterized the specific genotype of Hepatitis E virus from water bodies of Faisalabad, Pakistan. Drinking and sewage samples were qualitatively analyzed by using RT-PCR. HEV Genotype 1 strain was recovered from sewage water of Faisalabad. Prevalence of HEV and HAV in sewage water propose the possibility of gradual decline in the protection level of the circulated vaccine in the Pakistani population.

Background: A positive learning environment and quality of course content have an imperative role in academic achievement of students. This study aims to assess students' point of view about the quality of education and social environment of a public sector medical college in Pakistan. Relative scarcity of data from students' perspective merited this study., Methods: A cross-sectional survey was undertaken at Ayub Medical College, Abbottabad, Pakistan, including 300 medical students from all five years of the MBBS course. Systematic random sampling was used with a kth interval of 4 for each class. Self-administered questionnaire was used and contained items related to academics, learning environment, learning resources, teaching methodologies and student-friendly activities. The data were analysed using SPSS-16., Results: There were 265 respondents (88.3%) to the questionnaire with males accounting for 58.9% (n=156). In general students showed satisfaction with quality of content being taught; however there was discontent towards various academic and non- academic facilities provided to the students. Only 44.10% and 31.50% students reported provision of academic related facilities and interactive sessions as up to mark respectively; 83% students reported that undergraduate medical research was in need of improvement; 55.5% and 60.2% reported that facilities in hostel and recreational facilities needed improvement respectively; and 52.8% students stated presence of a healthy, student friendly, encouraging environment was not up to mark., Conclusion: Although course content and teaching methodologies are generally satisfactory, a healthy, student friendly, encouraging environment is vet to be created to help students foster their abilities completely.

This study assessed the concentrations of heavy metals such as cadmium (Cd), chromium (Cr), copper (Cu), manganese (Mn), nickel (Ni) and zinc (Zn) in agricultural soils and crops (fruits, grains and vegetable) and their possible human health risk in Swat District, northern Pakistan. Cd concentration was found higher than the limit (0.05 mg/kg) set by world health organization in 95% fruit and 100% vegetable samples. Moreover, the concentrations of Cr, Cu, Mn, Ni and Zn in the soils were shown significant correlations with those in the crops. The metal transfer factor (MTF) was found highest for Cd followed by Cr>Ni>Zn>Cu>Mn, while the health risk assessment revealed that there was no health risk for most of the heavy metals except Cd, which showed a high level of health risk index (HRI⩾10E-1) that would pose a potential health risk to the consumers., (Copyright © 2013 Elsevier Ltd. All rights reserved.)

Background: The success of the Global Polio Eradication Initiative was remarkable, but four countries - Afghanistan, Pakistan, India and Nigeria - never interrupted polio transmission. Pakistan reportedly achieved all milestones except interrupting virus transmission. The aim of the study was to establish valid and reliable estimate for: routine oral polio vaccine (OPV) coverage, logistics management and the quality of monitoring systems in health facilities, NIDs OPV coverage, the quality of NIDs service delivery in static centers and mobile teams, and to ultimately provide scientific evidence for tailoring future interventions., Methods: A cross-sectional study using lot quality assessment sampling was conducted in the District Nankana Sahib of Pakistan's Punjab province. Twenty primary health centers and their catchment areas were selected randomly as 'lots'. The study involved the evaluation of 1080 children aged 12-23 months for routine OPV coverage, 20 health centers for logistics management and quality of monitoring systems, 420 households for NIDs OPV coverage, 20 static centers and 20 mobile teams for quality of NIDs service delivery. Study instruments were designed according to WHO guidelines., Results: Five out of twenty lots were rejected for unacceptably low routine immunization coverage. The validity of coverage was questionable to extent that all lots were rejected. Among the 54.1% who were able to present immunization cards, only 74.0% had valid immunization. Routine coverage was significantly associated with card availability and socioeconomic factors. The main reasons for routine immunization failure were absence of a vaccinator and unawareness of need for immunization. Health workers (96.9%) were a major source of information. All of the 20 lots were rejected for poor compliance in logistics management and quality of monitoring systems. Mean compliance score and compliance percentage for logistics management were 5.4 +/- 2.0 (scale 0-9) and 59.4% while those for quality of monitoring systems were 3.3 +/- 1.2 (scale 0-6) and 54.2%. The 15 out of 20 lots were rejected for unacceptably low NIDs coverage by finger-mark. All of the 20 lots were rejected for poor NIDs service delivery (mean compliance score = 11.7 +/- 2.1 [scale 0-16]; compliance percentage = 72.8%)., Conclusion: Low coverage, both routine and during NIDs, and poor quality of logistics management, monitoring systems and NIDs service delivery were highlighted as major constraints in polio eradication and these should be considered in prioritizing future strategies.