A recent study conducted by researchers at the University of Navarra in Pamplona, Spain, explores the role of Sirtuin 2 (SIRT2) in aging and age-related diseases. The study found that SIRT2 levels in the brain increase with aging, suggesting that inhibiting this enzyme could be beneficial for neurodegenerative diseases. However, in the periphery, SIRT2 levels decrease with aging, and maintaining its expression is protective against age-related peripheral inflammation, insulin resistance, and cardiovascular diseases. The researchers conclude that further investigation is needed to determine whether pharmacological modulation of SIRT2 could be an effective and safe strategy for treating age-related diseases. [Extracted from the article]