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Introduction: Liposarcoma of the vulva is extremely rare, it represents a diagnostic challenge for the gynecologist as well as the pathologist, there are few cases reported in the literature. We present a case of pleomorphic liposarcoma of the vulva, the first reported at the National Oncological Institute in Panama. Case report: This is a 52-year-old woman with a one-year history of a tumor on the right labia majora of the vulva, with accelerated growth in recent months associated with ulceration. The biopsy reported high-grade malignant mesenchymal neoplasia. She was taken After surgery, hemivulvectomy and flap reconstruction, the resection margins were negative. Postoperative evolution without adverse events. Conclusions: Pleomorphic liposarcoma of the vulva is an extremely rare entity; biopsy of the vulvar tumor is crucial for planning surgery, the treatment of choice in most cases. Adjuvant treatment is individualized and follow-up could be close. [ABSTRACT FROM AUTHOR]

Background: Skin biopsy is the most important complementary technique for a dermatologist. Even though a great number of skin biopsies are performed every year in our hospital, to the best of our knowledge, there are no research studies about this matter. Objetive: To describe the histopathological diagnosis and clinical correlation of skin biopsies performed at the Dermatology Service of the \"Complejo Hospitalario Dr. Arnulfo Arias Madrid\" between October, 2006, and October, 2008. Materials and methods: It was a correlational, descriptive, retrospective and transversal study of all skin biopsies that met the selection criteria. Results: A total of 1,862 biopsies were performed in the study period, though only 1,706 were considered for the study. The other 156 biopsies were excluded because they did not have a clinical diagnosis; 66.5% were form female patients, and 20.6% form patients in the 50-59 age group; 99.6% of the specimens were skin samples and 36% were performed in the head. The biopsy reports had a clinical history (99%), macroscopic description (97.5%), and microscopic description (17.5%). The most frequent clinical and histopathological diagnosis was melanocytic nevi (14%). The histopathological diagnosis correlated with the clinical dermatological diagnosis in 67.5% of the cases. Conclusion: A total of 1,862 skin biopsies were performed in a two year period by the Dermatology Service of the \"Complejo Hospitalario Dr. Arnulfo Arias Madrid\". The histopathological and clinical dermatological diagnoses were the same in 67.5% of the 1,706 biopsies considered for the study. [ABSTRACT FROM AUTHOR]