1. Cerebrospinal fluid levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in subacute sclerosing panencephalitis.
- Author
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Ichiyama T, Matsushige T, Siba P, Suarkia D, Takasu T, Miki K, and Furukawa S
- Subjects
- Adolescent, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Female, Humans, Inflammation cerebrospinal fluid, Inflammation immunology, Inflammation physiopathology, Male, Papua New Guinea, Subacute Sclerosing Panencephalitis diagnosis, Subacute Sclerosing Panencephalitis immunology, Matrix Metalloproteinase 9 cerebrospinal fluid, Subacute Sclerosing Panencephalitis cerebrospinal fluid, Subacute Sclerosing Panencephalitis physiopathology, Tissue Inhibitor of Metalloproteinase-1 cerebrospinal fluid
- Abstract
Objectives: To investigate the brain inflammation and damage in subacute sclerosing panencephalitis (SSPE), the cerebrospinal fluid (CSF) concentrations of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) were determined in SSPE patients., Methods: CSF MMP-9 and TIMP-1 levels were measured in 23 patients with SSPE in Papua New Guinea by ELISA., Results: CSF MMP-9 levels and MMP-9/TIMP-1 ratios of SSPE patients were significantly higher than controls (p<0.001 and p=0.005, respectively). There were no significant differences in CSF TIMP-1 levels between SSPE patients and controls., Conclusions: Previous studies suggested that CSF MMP-9 levels reflect inflammatory damage to the brain. Our findings suggest that the MMP-9 level in CSF is an indicator of inflammatory damage to the brain in SSPE.
- Published
- 2008
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