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Your search keyword '"Kawahara N"' showing total 3 results
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3 results on '"Kawahara N"'

1. A new leishmanicidal saponin from Brunfelsia grandiflora.

Author

Fuchino H, Sekita S, Mori K, Kawahara N, Satake M, and Kiuchi F

Subjects
Animals, Antiprotozoal Agents chemistry, Molecular Structure, Peru, Plant Leaves chemistry, Saponins chemistry, Antiprotozoal Agents isolation & purification, Antiprotozoal Agents pharmacology, Leishmania major drug effects, Leishmaniasis, Cutaneous drug therapy, Plants, Medicinal chemistry, Saponins isolation & purification, Saponins pharmacology, Solanaceae chemistry
Abstract

A new furostan-type saponin (1) was isolated from the methanolic extract of Brunfelsia grandiflora leaves, together with four known compounds. The chemical structure of 1 was determined by spectroscopic analysis and chemical reaction to be 26-O-beta-D-glucopyranosyl 22alpha-methoxyfurost-3beta,26-diol 3-O-beta-D-xylopyranosyl(1-->3)-{beta-D-glucopyranosyl(1-->2)}-beta-D-glucopyranosyl(1-->4)-beta-D-glucopyranoside. Compound 1 showed potent leishmanicidal activity in vitro against Leishmania major.

Published
2008
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2. Sesterterpenoid from Gentianella alborosea.

Author

Kawahara N, Nozawa M, Flores D, Bonilla P, Sekita S, and Satake M

Subjects
Magnetic Resonance Spectroscopy, Peru, Sesterterpenes, Spectrophotometry, Infrared, Spectrophotometry, Ultraviolet, Terpenes chemistry, Plants, Medicinal chemistry, Terpenes isolation & purification
Abstract

The structure of a new type of sesterterpenoid, designated as alborosin, isolated from Gentianella alborosea, has been deduced from a spectroscopic investigation.

Published
2000
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3. A novel sesterterpenoid, nitiol, as a potent enhancer of IL-2 gene expression in a human T cell line, from the Peruvian folk medicine "Hercumpuri" (Gentianella nitida).

Author

Kawahara N, Nozawa M, Kurata A, Hakamatsuka T, Sekita S, and Satake M

Subjects
Cells, Cultured, Humans, Interleukin-2 genetics, Jurkat Cells drug effects, Jurkat Cells metabolism, Magnetic Resonance Spectroscopy, Peru, RNA, Messenger biosynthesis, T-Lymphocytes drug effects, Terpenes pharmacology, Gene Expression Regulation drug effects, Interleukin-2 biosynthesis, Plants, Medicinal chemistry, T-Lymphocytes metabolism, Terpenes isolation & purification
Abstract

A novel sesterterpenoid designated as nitiol (1), possessing enhancement activity of IL-2 gene expression in a human T cell line, was isolated from the Peruvian folk medicine "Hercampuri" (Gentianella nitida). The structure was elucidated by extensive spectroscopic investigation.

Published
1999
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