Search

The most important biothiols include glutathione, homocysteine (HCY), cysteine and proteins. The aim of the presented study was to evaluate the influence of lead on the biothiol turnover--the concentration of HCY and protein sulfhydryl groups (P-SH) in the serum and reduced glutathione (G-SH) in erythrocytes--in individuals (employees of metal works) exposed to lead and to evaluate its probable oxidative disorders, measured as the carbonyl protein (CP) concentration in serum. The exposed workers were divided into 2 subgroups: 1) low lead exposure (LPb), with a lead concentration in the blood (PbB) of 20-45 µg dl(-1) (n= 102), and 2) high lead exposure (HPb), with PbB = 45-60 µg dl(-1) (n= 81). The control group consisted of 72 office workers or other healthy subjects with no history of occupational exposure to lead. All the controls had normal PbB (<10 μg dl(-1)) and ZPP (<2.5 μg dl(-1)) levels. The concentration of HCY was higher in the LPb group by 11% and in the HPb group by 26%, compared with the control group (n=72). The CP concentration in these 2 groups was more than twice as high as that of the control group, with 108% and 125% increases for the LPb and HPb groups, respectively; G-SH was lower by 6.6% and 7.4% for the LPb and HPb groups, respectively; P-SH was lower by 8.2% and 13% for the LPb and HPb groups, respectively. Lead decreases levels of glutathione and protein thiol groups. Lead-induced oxidative stress contributes to the observed elevation of protein carbonyl groups. Besides, lead poisoning seems to be associated with hyperhomocysteinaemia, which may promote the development of atherosclerosis.

The main aim of the research was to define the degree of independence among patients after operative treatment femoral neck fractures in the first day after the operation and on day previous to the release from hospital. Attempt was made to determine the degree of independence in the ten activities of life, functional status and emotional state of patients. Efforts have also tried to assess the impact of functional status and emotional autonomy to the degree subjects. The study was conducted in Hospital in Poznan and Hospital in Chodziez, in the period from August 2006 March 2007. The research concerned 30 patients after operative treatment femoral neck fractures. To assess functional status, 100-point scale Barthel, to assess the emotional state HADS scale was used. Degree of independence was assessed Scale of Deficit Self-Care. The lack of independence was bigger among older patients in life activities like: moving, feed, drinking, expelling, personal sanitation and dressing. These patients required increasingly bigger medical care. Functional condition introduces considerably worst in older patients equal in research I and research II. Emotional status does not affect the degree of independence of patients, but in the first day after surgery, patients showing symptoms of depression had demanded a bigger range of assistance from medical personnel. Hip fracture have a negative impact on many areas of life activity of the patient, therefore, these patients require particularly caring therapeutic and rehabilitation activities.

The main aim of the research was to define the degree of independence among patients after operative treatment femoral neck fractures in the first day after the operation and on day previous to the release from hospital. Attempt was made to determine the degree of independence in the ten activities of life, functional status and emotional state of patients. Efforts have also tried to assess the impact of functional status and emotional autonomy to the degree subjects. The study was conducted in Hospital in Poznan and Hospital in Chodziez, in the period from August 2006 March 2007. The research concerned 30 patients after operative treatment femoral neck fractures. To assess functional status, 100-point scale Barthel, to assess the emotional state HADS scale was used. Degree of independence was assessed Scale of Deficit Self-Care. The lack of independence was bigger among older patients in life activities like: moving, feed, drinking, expelling, personal sanitation and dressing. These patients required increasingly bigger medical care. Functional condition introduces considerably worst in older patients equal in research I and research II. Emotional status does not affect the degree of independence of patients, but in the first day after surgery, patients showing symptoms of depression had demanded a bigger range of assistance from medical personnel. Hip fracture have a negative impact on many areas of life activity of the patient, therefore, these patients require particularly caring therapeutic and rehabilitation activities.