1. Transient Neonatal Diabetes Mellitus with an Unknown Cause in a 1-Month-Old Infant: A Case Report.
- Author
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Tarasiewicz, Mateusz, Pietrzykowska, Anna, Włodarczyk, Julia, Seget, Sebastian, Gadzalska, Karolina, Jakiel, Paulina, Skoczylas, Sebastian, Jarosz-Chobot, Przemysława, and Borowiec, Maciej
- Subjects
DIAGNOSIS of diabetes ,ULTRASONIC imaging of the abdomen ,GENETICS of diabetes ,TREATMENT of diabetes ,BLOOD gases analysis ,OLIGONUCLEOTIDE arrays ,FETAL hemoglobin ,AZYGOS vein ,GENOME-wide association studies ,GESTATIONAL diabetes ,NEONATAL intensive care units ,GLYCEMIC control ,INSULIN ,CHILDREN'S hospitals ,FAMILY history (Medicine) ,NEONATAL intensive care ,KETONES ,NEONATAL diseases ,HYPERGLYCEMIA ,BLOOD sugar ,GENETIC variation ,C-peptide ,INTRAVENOUS therapy ,CONTINUOUS glucose monitoring ,GENETIC mutation ,ACID-base equilibrium ,MITOCHONDRIAL DNA ,PHENOTYPES ,ECHOCARDIOGRAPHY ,SEQUENCE analysis ,BLOOD ,CHILDREN - Abstract
Transient neonatal diabetes mellitus (TNDM) is a genetically heterogeneous form of neonatal diabetes characterized by hyperglycemia that remits during infancy with a tendency to recur in later life. This case report presents the history of a male infant with transient neonatal diabetes mellitus. The patient was treated with a continuous subcutaneous insulin infusion (CSII) and a continuous glucose monitoring (CGM) system until the age of 2 months, when the normoglycemia connected with a withdrawal of treatment was noted. The genetic test results excluded the majority of known mutations related to TNDM. This case report focuses on various genetic mutations and the clinical features connected with them that cause TNDM and highlights the difficulties in the diagnostic and therapeutic processes of this disease. CSII and CGM systems seem to be a safe and effective treatment option in TNDM and may be used in the therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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